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Association between Body Water Status and Acute Mountain Sickness

PURPOSE: The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults. METHODS: Forty-three healthy participants (26 males and 17 females, age: 26±6 yr, height: 174±9 cm, weight: 68±12 kg) were passively exposed at a FiO(2)...

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Autores principales: Gatterer, Hannes, Wille, Maria, Faulhaber, Martin, Lukaski, Henry, Melmer, Andreas, Ebenbichler, Christoph, Burtscher, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754926/
https://www.ncbi.nlm.nih.gov/pubmed/24013267
http://dx.doi.org/10.1371/journal.pone.0073185
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author Gatterer, Hannes
Wille, Maria
Faulhaber, Martin
Lukaski, Henry
Melmer, Andreas
Ebenbichler, Christoph
Burtscher, Martin
author_facet Gatterer, Hannes
Wille, Maria
Faulhaber, Martin
Lukaski, Henry
Melmer, Andreas
Ebenbichler, Christoph
Burtscher, Martin
author_sort Gatterer, Hannes
collection PubMed
description PURPOSE: The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults. METHODS: Forty-three healthy participants (26 males and 17 females, age: 26±6 yr, height: 174±9 cm, weight: 68±12 kg) were passively exposed at a FiO(2) of 12.6% (simulated altitude hypoxia of 4500 m, PiO(2) = 83.9 mmHg) for 12-h. AMS severity was assessed using the Lake Louise Score (LLS). Food and drink intakes were consumed ad libitum and measured; all urine was collected. Before and after the 12-h exposure, body weight and plasma osmolality were measured and whole-body bioimpedance analysis was performed. RESULTS: The overall AMS incidence was 43% (38% males, 50% females). Participants who developed AMS showed lower fluid losses (3.0±0.9 vs. 4.5±2.0 ml/kg/h, p = 0.002), a higher fluid retention (1.9±1.5 vs. 0.6±0.8 ml/kg/h, p = 0.022), greater plasma osmolality decreases (−7±7 vs. −2±5 mOsm/kg, p = 0.028) and a larger plasma volume expansion (11±10 vs. 1±15%, p = 0.041) compared to participants not developing AMS. Net water balance (fluid intake – fluid loss) and the amount of fluid loss were strong predictors whether getting sick or not (Nagelkerkes r(2) = 0.532). The LLS score was related to net water balance (r = 0.358, p = 0.018), changes in plasma osmolality (r = −0.325, p = 0.033) and sodium concentration (r = −0.305, p = 0.047). Changes in the impedance vector length were related to weight changes (r = −0.550, p<0.001), fluid intake (r = −0.533, p<0.001) and net water balance (r = −0.590, p<0.001). CONCLUSIONS: Participants developing AMS within 12 hours showed a positive net water balance due to low fluid loss. Thus measures to avoid excess fluid retention are likely to reduce AMS symptoms.
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spelling pubmed-37549262013-09-06 Association between Body Water Status and Acute Mountain Sickness Gatterer, Hannes Wille, Maria Faulhaber, Martin Lukaski, Henry Melmer, Andreas Ebenbichler, Christoph Burtscher, Martin PLoS One Research Article PURPOSE: The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults. METHODS: Forty-three healthy participants (26 males and 17 females, age: 26±6 yr, height: 174±9 cm, weight: 68±12 kg) were passively exposed at a FiO(2) of 12.6% (simulated altitude hypoxia of 4500 m, PiO(2) = 83.9 mmHg) for 12-h. AMS severity was assessed using the Lake Louise Score (LLS). Food and drink intakes were consumed ad libitum and measured; all urine was collected. Before and after the 12-h exposure, body weight and plasma osmolality were measured and whole-body bioimpedance analysis was performed. RESULTS: The overall AMS incidence was 43% (38% males, 50% females). Participants who developed AMS showed lower fluid losses (3.0±0.9 vs. 4.5±2.0 ml/kg/h, p = 0.002), a higher fluid retention (1.9±1.5 vs. 0.6±0.8 ml/kg/h, p = 0.022), greater plasma osmolality decreases (−7±7 vs. −2±5 mOsm/kg, p = 0.028) and a larger plasma volume expansion (11±10 vs. 1±15%, p = 0.041) compared to participants not developing AMS. Net water balance (fluid intake – fluid loss) and the amount of fluid loss were strong predictors whether getting sick or not (Nagelkerkes r(2) = 0.532). The LLS score was related to net water balance (r = 0.358, p = 0.018), changes in plasma osmolality (r = −0.325, p = 0.033) and sodium concentration (r = −0.305, p = 0.047). Changes in the impedance vector length were related to weight changes (r = −0.550, p<0.001), fluid intake (r = −0.533, p<0.001) and net water balance (r = −0.590, p<0.001). CONCLUSIONS: Participants developing AMS within 12 hours showed a positive net water balance due to low fluid loss. Thus measures to avoid excess fluid retention are likely to reduce AMS symptoms. Public Library of Science 2013-08-27 /pmc/articles/PMC3754926/ /pubmed/24013267 http://dx.doi.org/10.1371/journal.pone.0073185 Text en © 2013 Gatterer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gatterer, Hannes
Wille, Maria
Faulhaber, Martin
Lukaski, Henry
Melmer, Andreas
Ebenbichler, Christoph
Burtscher, Martin
Association between Body Water Status and Acute Mountain Sickness
title Association between Body Water Status and Acute Mountain Sickness
title_full Association between Body Water Status and Acute Mountain Sickness
title_fullStr Association between Body Water Status and Acute Mountain Sickness
title_full_unstemmed Association between Body Water Status and Acute Mountain Sickness
title_short Association between Body Water Status and Acute Mountain Sickness
title_sort association between body water status and acute mountain sickness
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754926/
https://www.ncbi.nlm.nih.gov/pubmed/24013267
http://dx.doi.org/10.1371/journal.pone.0073185
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