Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)

We previously designed a new family of artificial proteins named αRep based on a subgroup of thermostable helicoidal HEAT-like repeats. We have now assembled a large optimized αRep library. In this library, the side chains at each variable position are not fully randomized but instead encoded by a d...

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Detalles Bibliográficos
Autores principales: Guellouz, Asma, Valerio-Lepiniec, Marie, Urvoas, Agathe, Chevrel, Anne, Graille, Marc, Fourati-Kammoun, Zaineb, Desmadril, Michel, van Tilbeurgh, Herman, Minard, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754942/
https://www.ncbi.nlm.nih.gov/pubmed/24014183
http://dx.doi.org/10.1371/journal.pone.0071512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754942/
https://www.ncbi.nlm.nih.gov/pubmed/24014183
http://dx.doi.org/10.1371/journal.pone.0071512

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