Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling

Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk is central to the multiple aberrantly modulated molecules in SLE T cells. Usi...

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Detalles Bibliográficos
Autores principales: Grammatikos, Alexandros P., Ghosh, Debjani, Devlin, Amy, Kyttaris, Vasileios C., Tsokos, George C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754955/
https://www.ncbi.nlm.nih.gov/pubmed/24013589
http://dx.doi.org/10.1371/journal.pone.0074550

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