Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom

To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting b...

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Detalles Bibliográficos
Autores principales: Seo, Dong-Soo, Lee, Eun-Na, Seo, Geon-Sik, Lee, Jong-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2008
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755194/
https://www.ncbi.nlm.nih.gov/pubmed/23997625
http://dx.doi.org/10.4489/MYCO.2008.36.3.195
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author Seo, Dong-Soo
Lee, Eun-Na
Seo, Geon-Sik
Lee, Jong-Soo
author_facet Seo, Dong-Soo
Lee, Eun-Na
Seo, Geon-Sik
Lee, Jong-Soo
author_sort Seo, Dong-Soo
collection PubMed
description To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h.
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spelling pubmed-37551942013-08-30 Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom Seo, Dong-Soo Lee, Eun-Na Seo, Geon-Sik Lee, Jong-Soo Mycobiology Note To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h. The Korean Society of Mycology 2008-09 2008-09-30 /pmc/articles/PMC3755194/ /pubmed/23997625 http://dx.doi.org/10.4489/MYCO.2008.36.3.195 Text en Copyright © 2008 The Korean Society of Mycology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Note
Seo, Dong-Soo
Lee, Eun-Na
Seo, Geon-Sik
Lee, Jong-Soo
Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
title Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
title_full Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
title_fullStr Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
title_full_unstemmed Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
title_short Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
title_sort screening and optimal extraction of a new antidementia β-secretase inhibitor-containing mushroom
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755194/
https://www.ncbi.nlm.nih.gov/pubmed/23997625
http://dx.doi.org/10.4489/MYCO.2008.36.3.195
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