Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at th...

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Autores principales: Chini, Eduardo Nunes, Chini, Claudia C. S., Nin, Veronica, Escande, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755336/
https://www.ncbi.nlm.nih.gov/pubmed/23841676
http://dx.doi.org/10.1042/BSR20130062
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author Chini, Eduardo Nunes
Chini, Claudia C. S.
Nin, Veronica
Escande, Carlos
author_facet Chini, Eduardo Nunes
Chini, Claudia C. S.
Nin, Veronica
Escande, Carlos
author_sort Chini, Eduardo Nunes
collection PubMed
description DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.
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spelling pubmed-37553362013-08-29 Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer Chini, Eduardo Nunes Chini, Claudia C. S. Nin, Veronica Escande, Carlos Biosci Rep Review Article DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer. Portland Press Ltd. 2013-08-23 /pmc/articles/PMC3755336/ /pubmed/23841676 http://dx.doi.org/10.1042/BSR20130062 Text en © 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chini, Eduardo Nunes
Chini, Claudia C. S.
Nin, Veronica
Escande, Carlos
Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
title Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
title_full Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
title_fullStr Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
title_full_unstemmed Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
title_short Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
title_sort deleted in breast cancer-1 (dbc-1) in the interface between metabolism, aging and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755336/
https://www.ncbi.nlm.nih.gov/pubmed/23841676
http://dx.doi.org/10.1042/BSR20130062
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