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An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model

Development of a vaccine against congenital cytomegalovirus (CMV) infection is a public health priority, but CMVs encode immune evasion genes that complicate live virus vaccine design. To resolve this problem, this study employed guanosyl phosphoribosyl transferase (gpt) mutagenesis to generate a re...

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Detalles Bibliográficos
Autores principales:	Leviton, Michael P., Lacayo, Juan C., Choi, K. Yeon, Hernandez-Alvarado, Nelmary, Wey, Andrew, Schleiss, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755440/ https://www.ncbi.nlm.nih.gov/pubmed/24000289 http://dx.doi.org/10.1155/2013/906948

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