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Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
BACKGROUND: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape™) containing 2....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755702/ https://www.ncbi.nlm.nih.gov/pubmed/24003309 http://dx.doi.org/10.2147/DMSO.S49623 |
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author | Zemel, Michael B Bruckbauer, Antje |
author_facet | Zemel, Michael B Bruckbauer, Antje |
author_sort | Zemel, Michael B |
collection | PubMed |
description | BACKGROUND: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape™) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by >30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition. METHODS: Two 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (−500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects. RESULTS: The supplement resulted in fat loss in the maintenance study (−1.12 ± 0.36 and −1.82 ± 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 ± 1.02 versus 3.40 ± 0.81 kg at 12 weeks and 8.15 ± 1.33 versus 5.25 ± 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 ± 0.61 versus 2.31 ± 0.53 kg at 12 weeks and 7.00 ± 0.95 versus 4.22 ± 0.74 kg at 24 weeks, P < 0.01) than the placebo group. CONCLUSION: This nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%–80% over a 24-week period. |
format | Online Article Text |
id | pubmed-3755702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37557022013-09-03 Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects Zemel, Michael B Bruckbauer, Antje Diabetes Metab Syndr Obes Original Research BACKGROUND: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape™) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by >30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition. METHODS: Two 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (−500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects. RESULTS: The supplement resulted in fat loss in the maintenance study (−1.12 ± 0.36 and −1.82 ± 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 ± 1.02 versus 3.40 ± 0.81 kg at 12 weeks and 8.15 ± 1.33 versus 5.25 ± 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 ± 0.61 versus 2.31 ± 0.53 kg at 12 weeks and 7.00 ± 0.95 versus 4.22 ± 0.74 kg at 24 weeks, P < 0.01) than the placebo group. CONCLUSION: This nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%–80% over a 24-week period. Dove Medical Press 2013-08-23 /pmc/articles/PMC3755702/ /pubmed/24003309 http://dx.doi.org/10.2147/DMSO.S49623 Text en © 2013 Zemel and Bruckbauer. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed. |
spellingShingle | Original Research Zemel, Michael B Bruckbauer, Antje Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
title | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
title_full | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
title_fullStr | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
title_full_unstemmed | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
title_short | Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
title_sort | effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755702/ https://www.ncbi.nlm.nih.gov/pubmed/24003309 http://dx.doi.org/10.2147/DMSO.S49623 |
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