Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)

Osteosarcoma is one of the most malignant tumors of childhood and adolescence that is often resistant to standard chemo- and radio-therapy. Geldanamycin and geldanamycin analogs have been recently studied as potential anticancer agents for osteosarcoma treatment. Here, for the first time, we have pr...

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Detalles Bibliográficos
Autores principales: Gorska, Magdalena, Marino Gammazza, Antonella, Zmijewski, Michal Aleksander, Campanella, Claudia, Cappello, Francesco, Wasiewicz, Tomasz, Kuban-Jankowska, Alicja, Daca, Agnieszka, Sielicka, Alicja, Popowska, Urszula, Knap, Narcyz, Antoniewicz, Jakub, Wakabayashi, Takashi, Wozniak, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756027/
https://www.ncbi.nlm.nih.gov/pubmed/24015183
http://dx.doi.org/10.1371/journal.pone.0071135

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