Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)

Leprechaunism is a rare autosomal recessive disease that is characterized by severe insulin resistance. This disease is caused by a defective insulin receptor and features abnormal glucose metabolism and retarded intrauterine and postnatal growth. However, there are few reports on the long-term cour...

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Autores principales: Jo, Wakako, Sudo, Satoko, Nakamura, Akie, Endo, Daisuke, Konno, Yosuke, Ishizu, Katsura, Tajima, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756185/
https://www.ncbi.nlm.nih.gov/pubmed/23990696
http://dx.doi.org/10.1297/cpe.22.33
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author Jo, Wakako
Sudo, Satoko
Nakamura, Akie
Endo, Daisuke
Konno, Yosuke
Ishizu, Katsura
Tajima, Toshihiro
author_facet Jo, Wakako
Sudo, Satoko
Nakamura, Akie
Endo, Daisuke
Konno, Yosuke
Ishizu, Katsura
Tajima, Toshihiro
author_sort Jo, Wakako
collection PubMed
description Leprechaunism is a rare autosomal recessive disease that is characterized by severe insulin resistance. This disease is caused by a defective insulin receptor and features abnormal glucose metabolism and retarded intrauterine and postnatal growth. However, there are few reports on the long-term course of leprechaunism. We reported the long-term clinical course and rh-IGF-1 treatment in a patient with leprechaunism. During follow-up her diabetes gradually deteriorated despite of treatment of rh-IGF-1. Furthermore, she developed endometrioid adenocarcinoma at the age of 24 yr. The development of endometrial disease must be carefully followed up in this disease.
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spelling pubmed-37561852013-08-29 Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome) Jo, Wakako Sudo, Satoko Nakamura, Akie Endo, Daisuke Konno, Yosuke Ishizu, Katsura Tajima, Toshihiro Clin Pediatr Endocrinol Case Report Leprechaunism is a rare autosomal recessive disease that is characterized by severe insulin resistance. This disease is caused by a defective insulin receptor and features abnormal glucose metabolism and retarded intrauterine and postnatal growth. However, there are few reports on the long-term course of leprechaunism. We reported the long-term clinical course and rh-IGF-1 treatment in a patient with leprechaunism. During follow-up her diabetes gradually deteriorated despite of treatment of rh-IGF-1. Furthermore, she developed endometrioid adenocarcinoma at the age of 24 yr. The development of endometrial disease must be carefully followed up in this disease. The Japanese Society for Pediatric Endocrinology 2013-04-26 2013-04 /pmc/articles/PMC3756185/ /pubmed/23990696 http://dx.doi.org/10.1297/cpe.22.33 Text en 2013©The Japanese Society for Pediatric Endocrinology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Case Report
Jo, Wakako
Sudo, Satoko
Nakamura, Akie
Endo, Daisuke
Konno, Yosuke
Ishizu, Katsura
Tajima, Toshihiro
Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)
title Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)
title_full Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)
title_fullStr Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)
title_full_unstemmed Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)
title_short Development of Endometrial Carcinoma in a Patient with Leprechaunism (Donohue Syndrome)
title_sort development of endometrial carcinoma in a patient with leprechaunism (donohue syndrome)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756185/
https://www.ncbi.nlm.nih.gov/pubmed/23990696
http://dx.doi.org/10.1297/cpe.22.33
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