Polycitorols A and B, New Tricyclic Alkaloids from an Ascidian

Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compoun...

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Detalles Bibliográficos
Autores principales: Issa, Hamad H., Tanaka, Junichi, Rachmat, Rachmaniar, Setiawan, Andi, Trianto, Agus, Higa, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2005
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756322/
Descripción
Sumario:Two new tricyclic alkaloids, polycitorols A (1) and B (2) have been isolated along with the known lepadiformine (3) from a marine ascidian of the family Polycitoridae. The structures of the new compounds were elucidated by analysis of NMR data and comparison with those of 3 and other related compounds [1–5]. Compounds 1 and 2 are closely related to cylindricines A and B, lacking C-4 oxygenation found in cylindricines and having a butyl instead of a hexyl appendage. NOE experiments on compounds 1 and 2 suggested the A/B ring fusion to be cis.

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