Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale

A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC(50) values of 11–45 μg/mL.

Detalles Bibliográficos
Autores principales: Tsukamoto, Sachiko, Koimaru, Keiichirou, Ohta, Tomihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2005
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756326/
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author Tsukamoto, Sachiko
Koimaru, Keiichirou
Ohta, Tomihisa
author_facet Tsukamoto, Sachiko
Koimaru, Keiichirou
Ohta, Tomihisa
author_sort Tsukamoto, Sachiko
collection PubMed
description A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC(50) values of 11–45 μg/mL.
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spelling pubmed-37563262013-08-29 Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale Tsukamoto, Sachiko Koimaru, Keiichirou Ohta, Tomihisa Mar Drugs Articles A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC(50) values of 11–45 μg/mL. Molecular Diversity Preservation International (MDPI) 2005-06-01 /pmc/articles/PMC3756326/ Text en © 2005 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Articles
Tsukamoto, Sachiko
Koimaru, Keiichirou
Ohta, Tomihisa
Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
title Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
title_full Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
title_fullStr Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
title_full_unstemmed Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
title_short Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
title_sort secomycalolide a: a new proteasome inhibitor isolated from a marine sponge of the genus mycale
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756326/
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AT koimarukeiichirou secomycalolideaanewproteasomeinhibitorisolatedfromamarinespongeofthegenusmycale
AT ohtatomihisa secomycalolideaanewproteasomeinhibitorisolatedfromamarinespongeofthegenusmycale

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