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Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice

Most Schistosoma mansoni experimental infections are developed in several inbred strains of Mus musculus as definitive host. In contrast, Mus spretus is unexplored in Schistosoma infection studies. Mus spretus provides a high variation of immunological phenotypes being an invaluable tool for genetic...

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Autores principales: Pérez del Villar, Luis, Vicente, Belén, Galindo-Villardón, Purificación, Castellanos, Andrés, Pérez-Losada, Jesús, Muro, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756336/
https://www.ncbi.nlm.nih.gov/pubmed/23985166
http://dx.doi.org/10.1051/parasite/2013027
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author Pérez del Villar, Luis
Vicente, Belén
Galindo-Villardón, Purificación
Castellanos, Andrés
Pérez-Losada, Jesús
Muro, Antonio
author_facet Pérez del Villar, Luis
Vicente, Belén
Galindo-Villardón, Purificación
Castellanos, Andrés
Pérez-Losada, Jesús
Muro, Antonio
author_sort Pérez del Villar, Luis
collection PubMed
description Most Schistosoma mansoni experimental infections are developed in several inbred strains of Mus musculus as definitive host. In contrast, Mus spretus is unexplored in Schistosoma infection studies. Mus spretus provides a high variation of immunological phenotypes being an invaluable tool for genetic studies and gene mapping. The aim of this study is to characterize hematological and immunological responses against Schistosoma mansoni infection in Mus spretus (SPRET/EiJ strain) vs. Mus musculus (CD1 strain) mice. Nine weeks after cercarial exposure, animals were perfused and the parasite burden was assessed. The parasitological data suggests that SPRET/EiJ mice tolerate higher parasite loads compared to CD1 strain. In addition, hematological parameters measured in Mus spretus group showed a significant increase in granulocytes population in early stages of infection compared to the CD1 cohort. Meanwhile, CD1 presented higher levels of lymphocytes and IgG1 in the late stages of S. mansoni experimental infection.
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spelling pubmed-37563362013-08-29 Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice Pérez del Villar, Luis Vicente, Belén Galindo-Villardón, Purificación Castellanos, Andrés Pérez-Losada, Jesús Muro, Antonio Parasite Short Note Most Schistosoma mansoni experimental infections are developed in several inbred strains of Mus musculus as definitive host. In contrast, Mus spretus is unexplored in Schistosoma infection studies. Mus spretus provides a high variation of immunological phenotypes being an invaluable tool for genetic studies and gene mapping. The aim of this study is to characterize hematological and immunological responses against Schistosoma mansoni infection in Mus spretus (SPRET/EiJ strain) vs. Mus musculus (CD1 strain) mice. Nine weeks after cercarial exposure, animals were perfused and the parasite burden was assessed. The parasitological data suggests that SPRET/EiJ mice tolerate higher parasite loads compared to CD1 strain. In addition, hematological parameters measured in Mus spretus group showed a significant increase in granulocytes population in early stages of infection compared to the CD1 cohort. Meanwhile, CD1 presented higher levels of lymphocytes and IgG1 in the late stages of S. mansoni experimental infection. EDP Sciences 2013 2013-08-29 /pmc/articles/PMC3756336/ /pubmed/23985166 http://dx.doi.org/10.1051/parasite/2013027 Text en © L. Pérez del Villar et al., published by EDP Sciences, 2013 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Note
Pérez del Villar, Luis
Vicente, Belén
Galindo-Villardón, Purificación
Castellanos, Andrés
Pérez-Losada, Jesús
Muro, Antonio
Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice
title Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice
title_full Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice
title_fullStr Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice
title_full_unstemmed Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice
title_short Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice
title_sort schistosoma mansoni experimental infection in mus spretus (spret/eij strain) mice
topic Short Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756336/
https://www.ncbi.nlm.nih.gov/pubmed/23985166
http://dx.doi.org/10.1051/parasite/2013027
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