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Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease
Aging is commonly defined as the accumulation of diverse deleterious changes in cells and tissues with advancing age. To investigate whether aging changes are involved in the lacrimal glands of chronic graft-versus-host disease (cGVHD) model mice, we obtained the specimens from cGVHD model mice, unt...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756340/ https://www.ncbi.nlm.nih.gov/pubmed/23986066 http://dx.doi.org/10.1038/srep02455 |
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author | Kawai, Masataka Ogawa, Yoko Shimmura, Shigeto Ohta, Shigeki Suzuki, Takanori Kawamura, Naoshi Kuwana, Masataka Kawakami, Yutaka Tsubota, Kazuo |
author_facet | Kawai, Masataka Ogawa, Yoko Shimmura, Shigeto Ohta, Shigeki Suzuki, Takanori Kawamura, Naoshi Kuwana, Masataka Kawakami, Yutaka Tsubota, Kazuo |
author_sort | Kawai, Masataka |
collection | PubMed |
description | Aging is commonly defined as the accumulation of diverse deleterious changes in cells and tissues with advancing age. To investigate whether aging changes are involved in the lacrimal glands of chronic graft-versus-host disease (cGVHD) model mice, we obtained the specimens from cGVHD model mice, untreated aged and young mice, and examined by histopathology, and immunoblotting. Oxidative stress markers, 8-OHdG, 4-HNE, and hexonoyl lesion (HEL), and other aging markers, p16 and p38, were used to assess the samples. The infiltrating mononuclear cells and endothelia of capillaries in the cGVHD and aged mice expressed the oxidative stress markers and other aging markers, but not in the young mice. Histological changes and the expression of aging markers in the samples from cGVHD mice exhibited similar features to those in aging mice. These results suggest that changes that typically appear with advanced age occur earlier in the lives of mice with lacrimal gland cGVHD. |
format | Online Article Text |
id | pubmed-3756340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37563402013-09-03 Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease Kawai, Masataka Ogawa, Yoko Shimmura, Shigeto Ohta, Shigeki Suzuki, Takanori Kawamura, Naoshi Kuwana, Masataka Kawakami, Yutaka Tsubota, Kazuo Sci Rep Article Aging is commonly defined as the accumulation of diverse deleterious changes in cells and tissues with advancing age. To investigate whether aging changes are involved in the lacrimal glands of chronic graft-versus-host disease (cGVHD) model mice, we obtained the specimens from cGVHD model mice, untreated aged and young mice, and examined by histopathology, and immunoblotting. Oxidative stress markers, 8-OHdG, 4-HNE, and hexonoyl lesion (HEL), and other aging markers, p16 and p38, were used to assess the samples. The infiltrating mononuclear cells and endothelia of capillaries in the cGVHD and aged mice expressed the oxidative stress markers and other aging markers, but not in the young mice. Histological changes and the expression of aging markers in the samples from cGVHD mice exhibited similar features to those in aging mice. These results suggest that changes that typically appear with advanced age occur earlier in the lives of mice with lacrimal gland cGVHD. Nature Publishing Group 2013-08-29 /pmc/articles/PMC3756340/ /pubmed/23986066 http://dx.doi.org/10.1038/srep02455 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Article Kawai, Masataka Ogawa, Yoko Shimmura, Shigeto Ohta, Shigeki Suzuki, Takanori Kawamura, Naoshi Kuwana, Masataka Kawakami, Yutaka Tsubota, Kazuo Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
title | Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
title_full | Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
title_fullStr | Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
title_full_unstemmed | Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
title_short | Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
title_sort | expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756340/ https://www.ncbi.nlm.nih.gov/pubmed/23986066 http://dx.doi.org/10.1038/srep02455 |
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