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Rational and Irrational Issues in Breast Cancer Screening

Evidence on the efficacy of breast screening from randomized controlled trials conducted in the last decades of the 1900s is reviewed. For decades, controversy about their results has centered on the magnitude of benefit in terms of breast cancer mortality reduction that can be achieved. However mor...

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Autor principal: Baines, Cornelia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756360/
https://www.ncbi.nlm.nih.gov/pubmed/24212617
http://dx.doi.org/10.3390/cancers3010252
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author Baines, Cornelia J.
author_facet Baines, Cornelia J.
author_sort Baines, Cornelia J.
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description Evidence on the efficacy of breast screening from randomized controlled trials conducted in the last decades of the 1900s is reviewed. For decades, controversy about their results has centered on the magnitude of benefit in terms of breast cancer mortality reduction that can be achieved. However more recently, several expert bodies have estimated the benefits to be smaller than initially expected and concerns have been raised about screening consequences such as over-diagnosis and unnecessary treatment. Trials with substantial mortality reduction have been lauded and others with null effects have been critiqued. Critiques of the Canadian National Breast Screening Study are refuted. Extreme responses by screening advocates to the United States Preventive Services Task Force 2009 guidelines are described. The role vested interests play in determining health policy is clearly revealed in the response to the guidelines and should be more generally known. A general reluctance to explore unexpected results or to accept new paradigms is briefly discussed.
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spelling pubmed-37563602013-09-04 Rational and Irrational Issues in Breast Cancer Screening Baines, Cornelia J. Cancers (Basel) Review Evidence on the efficacy of breast screening from randomized controlled trials conducted in the last decades of the 1900s is reviewed. For decades, controversy about their results has centered on the magnitude of benefit in terms of breast cancer mortality reduction that can be achieved. However more recently, several expert bodies have estimated the benefits to be smaller than initially expected and concerns have been raised about screening consequences such as over-diagnosis and unnecessary treatment. Trials with substantial mortality reduction have been lauded and others with null effects have been critiqued. Critiques of the Canadian National Breast Screening Study are refuted. Extreme responses by screening advocates to the United States Preventive Services Task Force 2009 guidelines are described. The role vested interests play in determining health policy is clearly revealed in the response to the guidelines and should be more generally known. A general reluctance to explore unexpected results or to accept new paradigms is briefly discussed. Molecular Diversity Preservation International (MDPI) 2011-01-11 /pmc/articles/PMC3756360/ /pubmed/24212617 http://dx.doi.org/10.3390/cancers3010252 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Baines, Cornelia J.
Rational and Irrational Issues in Breast Cancer Screening
title Rational and Irrational Issues in Breast Cancer Screening
title_full Rational and Irrational Issues in Breast Cancer Screening
title_fullStr Rational and Irrational Issues in Breast Cancer Screening
title_full_unstemmed Rational and Irrational Issues in Breast Cancer Screening
title_short Rational and Irrational Issues in Breast Cancer Screening
title_sort rational and irrational issues in breast cancer screening
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756360/
https://www.ncbi.nlm.nih.gov/pubmed/24212617
http://dx.doi.org/10.3390/cancers3010252
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