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Rational and Irrational Issues in Breast Cancer Screening
Evidence on the efficacy of breast screening from randomized controlled trials conducted in the last decades of the 1900s is reviewed. For decades, controversy about their results has centered on the magnitude of benefit in terms of breast cancer mortality reduction that can be achieved. However mor...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756360/ https://www.ncbi.nlm.nih.gov/pubmed/24212617 http://dx.doi.org/10.3390/cancers3010252 |
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author | Baines, Cornelia J. |
author_facet | Baines, Cornelia J. |
author_sort | Baines, Cornelia J. |
collection | PubMed |
description | Evidence on the efficacy of breast screening from randomized controlled trials conducted in the last decades of the 1900s is reviewed. For decades, controversy about their results has centered on the magnitude of benefit in terms of breast cancer mortality reduction that can be achieved. However more recently, several expert bodies have estimated the benefits to be smaller than initially expected and concerns have been raised about screening consequences such as over-diagnosis and unnecessary treatment. Trials with substantial mortality reduction have been lauded and others with null effects have been critiqued. Critiques of the Canadian National Breast Screening Study are refuted. Extreme responses by screening advocates to the United States Preventive Services Task Force 2009 guidelines are described. The role vested interests play in determining health policy is clearly revealed in the response to the guidelines and should be more generally known. A general reluctance to explore unexpected results or to accept new paradigms is briefly discussed. |
format | Online Article Text |
id | pubmed-3756360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37563602013-09-04 Rational and Irrational Issues in Breast Cancer Screening Baines, Cornelia J. Cancers (Basel) Review Evidence on the efficacy of breast screening from randomized controlled trials conducted in the last decades of the 1900s is reviewed. For decades, controversy about their results has centered on the magnitude of benefit in terms of breast cancer mortality reduction that can be achieved. However more recently, several expert bodies have estimated the benefits to be smaller than initially expected and concerns have been raised about screening consequences such as over-diagnosis and unnecessary treatment. Trials with substantial mortality reduction have been lauded and others with null effects have been critiqued. Critiques of the Canadian National Breast Screening Study are refuted. Extreme responses by screening advocates to the United States Preventive Services Task Force 2009 guidelines are described. The role vested interests play in determining health policy is clearly revealed in the response to the guidelines and should be more generally known. A general reluctance to explore unexpected results or to accept new paradigms is briefly discussed. Molecular Diversity Preservation International (MDPI) 2011-01-11 /pmc/articles/PMC3756360/ /pubmed/24212617 http://dx.doi.org/10.3390/cancers3010252 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Baines, Cornelia J. Rational and Irrational Issues in Breast Cancer Screening |
title | Rational and Irrational Issues in Breast Cancer Screening |
title_full | Rational and Irrational Issues in Breast Cancer Screening |
title_fullStr | Rational and Irrational Issues in Breast Cancer Screening |
title_full_unstemmed | Rational and Irrational Issues in Breast Cancer Screening |
title_short | Rational and Irrational Issues in Breast Cancer Screening |
title_sort | rational and irrational issues in breast cancer screening |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756360/ https://www.ncbi.nlm.nih.gov/pubmed/24212617 http://dx.doi.org/10.3390/cancers3010252 |
work_keys_str_mv | AT bainescorneliaj rationalandirrationalissuesinbreastcancerscreening |