Cancer Stem Cells in Head and Neck Cancer

Head and neck cancer (HNC) is the sixth most common malignancy world-wide, however the survival rate has not improved for the past 20 years. In recent years, the cancer stem cell (CSC) hypothesis has gained ground in several malignancies and there is mounting evidence suggesting CSCs mediate tumor r...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitra, Doyel, Malkoski, Stephen P., Wang, Xiao-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756369/
https://www.ncbi.nlm.nih.gov/pubmed/24212622
http://dx.doi.org/10.3390/cancers3010415
_version_ 1782282083279831040
author Mitra, Doyel
Malkoski, Stephen P.
Wang, Xiao-Jing
author_facet Mitra, Doyel
Malkoski, Stephen P.
Wang, Xiao-Jing
author_sort Mitra, Doyel
collection PubMed
description Head and neck cancer (HNC) is the sixth most common malignancy world-wide, however the survival rate has not improved for the past 20 years. In recent years, the cancer stem cell (CSC) hypothesis has gained ground in several malignancies and there is mounting evidence suggesting CSCs mediate tumor resistance to chemotherapy and radiation therapy. However, the CSC theory is also challenged at least in certain types of cancer. Here we review the progress of CSC studies in HNC, which suggest that HNC conforms to the CSC model. The identified CSC markers and their tumor initiation properties provide a framework for the development of novel therapeutic strategies for HNC.
format Online
Article
Text
id pubmed-3756369
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-37563692013-09-04 Cancer Stem Cells in Head and Neck Cancer Mitra, Doyel Malkoski, Stephen P. Wang, Xiao-Jing Cancers (Basel) Review Head and neck cancer (HNC) is the sixth most common malignancy world-wide, however the survival rate has not improved for the past 20 years. In recent years, the cancer stem cell (CSC) hypothesis has gained ground in several malignancies and there is mounting evidence suggesting CSCs mediate tumor resistance to chemotherapy and radiation therapy. However, the CSC theory is also challenged at least in certain types of cancer. Here we review the progress of CSC studies in HNC, which suggest that HNC conforms to the CSC model. The identified CSC markers and their tumor initiation properties provide a framework for the development of novel therapeutic strategies for HNC. Molecular Diversity Preservation International (MDPI) 2011-01-20 /pmc/articles/PMC3756369/ /pubmed/24212622 http://dx.doi.org/10.3390/cancers3010415 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Mitra, Doyel
Malkoski, Stephen P.
Wang, Xiao-Jing
Cancer Stem Cells in Head and Neck Cancer
title Cancer Stem Cells in Head and Neck Cancer
title_full Cancer Stem Cells in Head and Neck Cancer
title_fullStr Cancer Stem Cells in Head and Neck Cancer
title_full_unstemmed Cancer Stem Cells in Head and Neck Cancer
title_short Cancer Stem Cells in Head and Neck Cancer
title_sort cancer stem cells in head and neck cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756369/
https://www.ncbi.nlm.nih.gov/pubmed/24212622
http://dx.doi.org/10.3390/cancers3010415
work_keys_str_mv AT mitradoyel cancerstemcellsinheadandneckcancer
AT malkoskistephenp cancerstemcellsinheadandneckcancer
AT wangxiaojing cancerstemcellsinheadandneckcancer

Ejemplares similares