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Nerve Growth Factor in Cancer Cell Death and Survival
One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that neurotrophins contribute to pro-survival signaling in many different types of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756375/ https://www.ncbi.nlm.nih.gov/pubmed/24212627 http://dx.doi.org/10.3390/cancers3010510 |
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author | Molloy, Niamh H. Read, Danielle E. Gorman, Adrienne M. |
author_facet | Molloy, Niamh H. Read, Danielle E. Gorman, Adrienne M. |
author_sort | Molloy, Niamh H. |
collection | PubMed |
description | One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that neurotrophins contribute to pro-survival signaling in many different types of cancer. In particular, nerve growth factor, the archetypal neurotrophin, has been shown to play a role in tumorigenesis over the past decade. Nerve growth factor mediates its effects through its two cognate receptors, TrkA, a receptor tyrosine kinase and p75(NTR), a member of the death receptor superfamily. Depending on the tumor origin, pro-survival signaling can be mediated by TrkA receptors or by p75(NTR). For example, in breast cancer the aberrant expression of nerve growth factor stimulates proliferative signaling through TrkA and pro-survival signaling through p75(NTR). This latter signaling through p75(NTR) promotes increased resistance to the induction of cell death by chemotherapeutic treatments. In contrast, in prostate cells the p75(NTR) mediates cell death and prevents metastasis. In prostate cancer, expression of this receptor is lost, which contributes to tumor progression by allowing cells to survive, proliferate and metastasize. This review focuses on our current knowledge of neurotrophin signaling in cancer, with a particular emphasis on nerve growth factor regulation of cell death and survival in cancer. |
format | Online Article Text |
id | pubmed-3756375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37563752013-09-04 Nerve Growth Factor in Cancer Cell Death and Survival Molloy, Niamh H. Read, Danielle E. Gorman, Adrienne M. Cancers (Basel) Review One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that neurotrophins contribute to pro-survival signaling in many different types of cancer. In particular, nerve growth factor, the archetypal neurotrophin, has been shown to play a role in tumorigenesis over the past decade. Nerve growth factor mediates its effects through its two cognate receptors, TrkA, a receptor tyrosine kinase and p75(NTR), a member of the death receptor superfamily. Depending on the tumor origin, pro-survival signaling can be mediated by TrkA receptors or by p75(NTR). For example, in breast cancer the aberrant expression of nerve growth factor stimulates proliferative signaling through TrkA and pro-survival signaling through p75(NTR). This latter signaling through p75(NTR) promotes increased resistance to the induction of cell death by chemotherapeutic treatments. In contrast, in prostate cells the p75(NTR) mediates cell death and prevents metastasis. In prostate cancer, expression of this receptor is lost, which contributes to tumor progression by allowing cells to survive, proliferate and metastasize. This review focuses on our current knowledge of neurotrophin signaling in cancer, with a particular emphasis on nerve growth factor regulation of cell death and survival in cancer. Molecular Diversity Preservation International (MDPI) 2011-02-01 /pmc/articles/PMC3756375/ /pubmed/24212627 http://dx.doi.org/10.3390/cancers3010510 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Molloy, Niamh H. Read, Danielle E. Gorman, Adrienne M. Nerve Growth Factor in Cancer Cell Death and Survival |
title | Nerve Growth Factor in Cancer Cell Death and Survival |
title_full | Nerve Growth Factor in Cancer Cell Death and Survival |
title_fullStr | Nerve Growth Factor in Cancer Cell Death and Survival |
title_full_unstemmed | Nerve Growth Factor in Cancer Cell Death and Survival |
title_short | Nerve Growth Factor in Cancer Cell Death and Survival |
title_sort | nerve growth factor in cancer cell death and survival |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756375/ https://www.ncbi.nlm.nih.gov/pubmed/24212627 http://dx.doi.org/10.3390/cancers3010510 |
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