Cargando…

Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease

Pancreatic cancer is difficult to cure, so its prevention is very important. For this purpose, animal model studies are necessary to develop effective methods. Injection of N-nitrosobis(2-oxopropyl)amine (BOP) into Syrian golden hamsters is known to induce pancreatic ductal adenocarcinomas, the hist...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Mami, Hori, Mika, Mutoh, Michihiro, Wakabayashi, Keiji, Nakagama, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756378/
https://www.ncbi.nlm.nih.gov/pubmed/24212630
http://dx.doi.org/10.3390/cancers3010582
_version_ 1782282085086527488
author Takahashi, Mami
Hori, Mika
Mutoh, Michihiro
Wakabayashi, Keiji
Nakagama, Hitoshi
author_facet Takahashi, Mami
Hori, Mika
Mutoh, Michihiro
Wakabayashi, Keiji
Nakagama, Hitoshi
author_sort Takahashi, Mami
collection PubMed
description Pancreatic cancer is difficult to cure, so its prevention is very important. For this purpose, animal model studies are necessary to develop effective methods. Injection of N-nitrosobis(2-oxopropyl)amine (BOP) into Syrian golden hamsters is known to induce pancreatic ductal adenocarcinomas, the histology of which is similar to human tumors. Moreover, K-ras activation by point mutations and p16 inactivation by aberrant methylation of 5′ CpG islands or by homozygous deletions have been frequently observed in common in both the hamster and humans. Thus, this chemical carcinogenesis model has an advantage of histopathological and genetic similarity to human pancreatic cancer, and it is useful to study promotive and suppressive factors. Syrian golden hamsters are in a hyperlipidemic state even under normal dietary conditions, and a ligand of peroxizome proliferator-activated receptor gamma was found to improve the hyperlipidemia and suppress pancreatic carcinogenesis. Chronic inflammation is a known important risk factor, and selective inhibitors of inducible nitric oxide synthase and cyclooxygenase-2 also have protective effects against pancreatic cancer development. Anti-inflammatory and anti-hyperlipidemic agents can thus be considered candidate chemopreventive agents deserving more attention.
format Online
Article
Text
id pubmed-3756378
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-37563782013-09-04 Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease Takahashi, Mami Hori, Mika Mutoh, Michihiro Wakabayashi, Keiji Nakagama, Hitoshi Cancers (Basel) Review Pancreatic cancer is difficult to cure, so its prevention is very important. For this purpose, animal model studies are necessary to develop effective methods. Injection of N-nitrosobis(2-oxopropyl)amine (BOP) into Syrian golden hamsters is known to induce pancreatic ductal adenocarcinomas, the histology of which is similar to human tumors. Moreover, K-ras activation by point mutations and p16 inactivation by aberrant methylation of 5′ CpG islands or by homozygous deletions have been frequently observed in common in both the hamster and humans. Thus, this chemical carcinogenesis model has an advantage of histopathological and genetic similarity to human pancreatic cancer, and it is useful to study promotive and suppressive factors. Syrian golden hamsters are in a hyperlipidemic state even under normal dietary conditions, and a ligand of peroxizome proliferator-activated receptor gamma was found to improve the hyperlipidemia and suppress pancreatic carcinogenesis. Chronic inflammation is a known important risk factor, and selective inhibitors of inducible nitric oxide synthase and cyclooxygenase-2 also have protective effects against pancreatic cancer development. Anti-inflammatory and anti-hyperlipidemic agents can thus be considered candidate chemopreventive agents deserving more attention. Molecular Diversity Preservation International (MDPI) 2011-02-09 /pmc/articles/PMC3756378/ /pubmed/24212630 http://dx.doi.org/10.3390/cancers3010582 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Takahashi, Mami
Hori, Mika
Mutoh, Michihiro
Wakabayashi, Keiji
Nakagama, Hitoshi
Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease
title Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease
title_full Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease
title_fullStr Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease
title_full_unstemmed Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease
title_short Experimental Animal Models of Pancreatic Carcinogenesis for Prevention Studies and Their Relevance to Human Disease
title_sort experimental animal models of pancreatic carcinogenesis for prevention studies and their relevance to human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756378/
https://www.ncbi.nlm.nih.gov/pubmed/24212630
http://dx.doi.org/10.3390/cancers3010582
work_keys_str_mv AT takahashimami experimentalanimalmodelsofpancreaticcarcinogenesisforpreventionstudiesandtheirrelevancetohumandisease
AT horimika experimentalanimalmodelsofpancreaticcarcinogenesisforpreventionstudiesandtheirrelevancetohumandisease
AT mutohmichihiro experimentalanimalmodelsofpancreaticcarcinogenesisforpreventionstudiesandtheirrelevancetohumandisease
AT wakabayashikeiji experimentalanimalmodelsofpancreaticcarcinogenesisforpreventionstudiesandtheirrelevancetohumandisease
AT nakagamahitoshi experimentalanimalmodelsofpancreaticcarcinogenesisforpreventionstudiesandtheirrelevancetohumandisease