Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells

Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterp...

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Detalles Bibliográficos
Autores principales: Schmalz, Philip G.R., Shen, Michael J., Park, John K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756380/
https://www.ncbi.nlm.nih.gov/pubmed/24212632
http://dx.doi.org/10.3390/cancers3010621
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author Schmalz, Philip G.R.
Shen, Michael J.
Park, John K.
author_facet Schmalz, Philip G.R.
Shen, Michael J.
Park, John K.
author_sort Schmalz, Philip G.R.
collection PubMed
description Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.
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spelling pubmed-37563802013-09-04 Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells Schmalz, Philip G.R. Shen, Michael J. Park, John K. Cancers (Basel) Review Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed. Molecular Diversity Preservation International (MDPI) 2011-02-10 /pmc/articles/PMC3756380/ /pubmed/24212632 http://dx.doi.org/10.3390/cancers3010621 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Schmalz, Philip G.R.
Shen, Michael J.
Park, John K.
Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
title Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
title_full Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
title_fullStr Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
title_full_unstemmed Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
title_short Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells
title_sort treatment resistance mechanisms of malignant glioma tumor stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756380/
https://www.ncbi.nlm.nih.gov/pubmed/24212632
http://dx.doi.org/10.3390/cancers3010621
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