The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status

The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC st...

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Autores principales: Kruschewski, Martin, Mueller, Kathrin, Lipka, Sybille, Budczies, Jan, Noske, Aurelia, Buhr, Heinz Johannes, Elezkurtaj, Sefer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756413/
https://www.ncbi.nlm.nih.gov/pubmed/24212661
http://dx.doi.org/10.3390/cancers3011274
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author Kruschewski, Martin
Mueller, Kathrin
Lipka, Sybille
Budczies, Jan
Noske, Aurelia
Buhr, Heinz Johannes
Elezkurtaj, Sefer
author_facet Kruschewski, Martin
Mueller, Kathrin
Lipka, Sybille
Budczies, Jan
Noske, Aurelia
Buhr, Heinz Johannes
Elezkurtaj, Sefer
author_sort Kruschewski, Martin
collection PubMed
description The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21− combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21− carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status.
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spelling pubmed-37564132013-09-04 The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status Kruschewski, Martin Mueller, Kathrin Lipka, Sybille Budczies, Jan Noske, Aurelia Buhr, Heinz Johannes Elezkurtaj, Sefer Cancers (Basel) Article The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21− combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21− carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status. Molecular Diversity Preservation International (MDPI) 2011-03-11 /pmc/articles/PMC3756413/ /pubmed/24212661 http://dx.doi.org/10.3390/cancers3011274 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kruschewski, Martin
Mueller, Kathrin
Lipka, Sybille
Budczies, Jan
Noske, Aurelia
Buhr, Heinz Johannes
Elezkurtaj, Sefer
The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status
title The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status
title_full The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status
title_fullStr The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status
title_full_unstemmed The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status
title_short The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status
title_sort prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756413/
https://www.ncbi.nlm.nih.gov/pubmed/24212661
http://dx.doi.org/10.3390/cancers3011274
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