Cargando…
Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling
Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response. Since many years it has been known that both calcium release from...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756424/ https://www.ncbi.nlm.nih.gov/pubmed/24009611 http://dx.doi.org/10.3389/fimmu.2013.00259 |
_version_ | 1782282094564605952 |
---|---|
author | Ernst, Insa M. A. Fliegert, Ralf Guse, Andreas H. |
author_facet | Ernst, Insa M. A. Fliegert, Ralf Guse, Andreas H. |
author_sort | Ernst, Insa M. A. |
collection | PubMed |
description | Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response. Since many years it has been known that both calcium release from intracellular stores and calcium entry via plasma membrane calcium channels are involved in shaping spatio-temporal calcium signals. Second messengers derived from the adenine dinucleotides NAD and NADP have been implicated in T cell calcium signaling. Nicotinic acid adenine dinucleotide phosphate (NAADP) acts as a very early second messenger upon T cell receptor/CD3 engagement, while cyclic ADP-ribose (cADPR) is mainly involved in sustained partial depletion of the endoplasmic reticulum by stimulating calcium release via ryanodine receptors. Finally, adenosine diphosphoribose (ADPR) a breakdown product of both NAD and cADPR activates a plasma membrane cation channel termed TRPM2 thereby facilitating calcium (and sodium) entry into T cells. Receptor-mediated formation, metabolism, and mode of action of these novel second messengers in T-lymphocytes will be reviewed. |
format | Online Article Text |
id | pubmed-3756424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37564242013-09-04 Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling Ernst, Insa M. A. Fliegert, Ralf Guse, Andreas H. Front Immunol Immunology Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response. Since many years it has been known that both calcium release from intracellular stores and calcium entry via plasma membrane calcium channels are involved in shaping spatio-temporal calcium signals. Second messengers derived from the adenine dinucleotides NAD and NADP have been implicated in T cell calcium signaling. Nicotinic acid adenine dinucleotide phosphate (NAADP) acts as a very early second messenger upon T cell receptor/CD3 engagement, while cyclic ADP-ribose (cADPR) is mainly involved in sustained partial depletion of the endoplasmic reticulum by stimulating calcium release via ryanodine receptors. Finally, adenosine diphosphoribose (ADPR) a breakdown product of both NAD and cADPR activates a plasma membrane cation channel termed TRPM2 thereby facilitating calcium (and sodium) entry into T cells. Receptor-mediated formation, metabolism, and mode of action of these novel second messengers in T-lymphocytes will be reviewed. Frontiers Media S.A. 2013-08-29 /pmc/articles/PMC3756424/ /pubmed/24009611 http://dx.doi.org/10.3389/fimmu.2013.00259 Text en Copyright © 2013 Ernst, Fliegert and Guse. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ernst, Insa M. A. Fliegert, Ralf Guse, Andreas H. Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling |
title | Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling |
title_full | Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling |
title_fullStr | Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling |
title_full_unstemmed | Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling |
title_short | Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling |
title_sort | adenine dinucleotide second messengers and t-lymphocyte calcium signaling |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756424/ https://www.ncbi.nlm.nih.gov/pubmed/24009611 http://dx.doi.org/10.3389/fimmu.2013.00259 |
work_keys_str_mv | AT ernstinsama adeninedinucleotidesecondmessengersandtlymphocytecalciumsignaling AT fliegertralf adeninedinucleotidesecondmessengersandtlymphocytecalciumsignaling AT guseandreash adeninedinucleotidesecondmessengersandtlymphocytecalciumsignaling |