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A New Tiapride Selective Electrode and Its Clinical Application
The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB(-)) in a plastici...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756728/ |
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author | Ortuño, Joaquín A. Ródenas, Vicente García, Mª Soledad Albero, Mª Isabel Sánchez-Pedreño, Concepción |
author_facet | Ortuño, Joaquín A. Ródenas, Vicente García, Mª Soledad Albero, Mª Isabel Sánchez-Pedreño, Concepción |
author_sort | Ortuño, Joaquín A. |
collection | PubMed |
description | The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB(-)) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10(-5)-1x10(-2) M) with a slope of 57.5±0.2 mV dec(-1) of concentration, a detection limit of 4.3x10(-6)±2.5x10(-7) M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution. |
format | Online Article Text |
id | pubmed-3756728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37567282013-08-29 A New Tiapride Selective Electrode and Its Clinical Application Ortuño, Joaquín A. Ródenas, Vicente García, Mª Soledad Albero, Mª Isabel Sánchez-Pedreño, Concepción Sensors (Basel) Full Research Paper The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB(-)) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10(-5)-1x10(-2) M) with a slope of 57.5±0.2 mV dec(-1) of concentration, a detection limit of 4.3x10(-6)±2.5x10(-7) M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution. Molecular Diversity Preservation International (MDPI) 2007-03-27 /pmc/articles/PMC3756728/ Text en © 2007 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes. |
spellingShingle | Full Research Paper Ortuño, Joaquín A. Ródenas, Vicente García, Mª Soledad Albero, Mª Isabel Sánchez-Pedreño, Concepción A New Tiapride Selective Electrode and Its Clinical Application |
title | A New Tiapride Selective Electrode and Its Clinical Application |
title_full | A New Tiapride Selective Electrode and Its Clinical Application |
title_fullStr | A New Tiapride Selective Electrode and Its Clinical Application |
title_full_unstemmed | A New Tiapride Selective Electrode and Its Clinical Application |
title_short | A New Tiapride Selective Electrode and Its Clinical Application |
title_sort | new tiapride selective electrode and its clinical application |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756728/ |
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