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Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
Part I describes important contributions made by some Japanese pioneers in the field of neurotransmitters: (their achievements in parentheses) J. Takamine (isolation and crystallization of adrenaline); K. Shimidzu (early hint for acetylcholine as a neurotransmitter); F. Kanematsu (donation of the Ka...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japan Academy
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756739/ https://www.ncbi.nlm.nih.gov/pubmed/24019584 |
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author | Otsuka, Masanori |
author_facet | Otsuka, Masanori |
author_sort | Otsuka, Masanori |
collection | PubMed |
description | Part I describes important contributions made by some Japanese pioneers in the field of neurotransmitters: (their achievements in parentheses) J. Takamine (isolation and crystallization of adrenaline); K. Shimidzu (early hint for acetylcholine as a neurotransmitter); F. Kanematsu (donation of the Kanematsu Memorial Institute in Sydney); T. Hayashi (discovery of the excitatory action of glutamate and the inhibitory action of GABA); and I. Sano (discovery of a high concentration of dopamine in striatum, its reduction in a patient with Parkinson’s disease and the treatment with DOPA). In Part II, I present some of my reflections on my research on neurotransmitters. The work of my colleagues and myself has made some significant contributions to the establishment of neurotransmitter roles played by GABA and substance P, the first amino acid and the first peptide neurotransmitters, respectively. By the early 1960s, 3 substances, i.e., acetylcholine, noradrenaline, and adrenaline, had been established as neurotransmitters. Now the number of neurotransmitters is believed to be as many as 50 or even more mainly due to the inclusion of several amino acids and a large number of peptide transmitters. |
format | Online Article Text |
id | pubmed-3756739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Japan Academy |
record_format | MEDLINE/PubMed |
spelling | pubmed-37567392013-09-09 Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research Otsuka, Masanori Proc Jpn Acad Ser B Phys Biol Sci Review Part I describes important contributions made by some Japanese pioneers in the field of neurotransmitters: (their achievements in parentheses) J. Takamine (isolation and crystallization of adrenaline); K. Shimidzu (early hint for acetylcholine as a neurotransmitter); F. Kanematsu (donation of the Kanematsu Memorial Institute in Sydney); T. Hayashi (discovery of the excitatory action of glutamate and the inhibitory action of GABA); and I. Sano (discovery of a high concentration of dopamine in striatum, its reduction in a patient with Parkinson’s disease and the treatment with DOPA). In Part II, I present some of my reflections on my research on neurotransmitters. The work of my colleagues and myself has made some significant contributions to the establishment of neurotransmitter roles played by GABA and substance P, the first amino acid and the first peptide neurotransmitters, respectively. By the early 1960s, 3 substances, i.e., acetylcholine, noradrenaline, and adrenaline, had been established as neurotransmitters. Now the number of neurotransmitters is believed to be as many as 50 or even more mainly due to the inclusion of several amino acids and a large number of peptide transmitters. The Japan Academy 2007-03 /pmc/articles/PMC3756739/ /pubmed/24019584 Text en © 2007 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Otsuka, Masanori Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research |
title | Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research |
title_full | Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research |
title_fullStr | Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research |
title_full_unstemmed | Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research |
title_short | Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research |
title_sort | contributions to the field of neurotransmitters by japanese scientists, and reflections on my own research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756739/ https://www.ncbi.nlm.nih.gov/pubmed/24019584 |
work_keys_str_mv | AT otsukamasanori contributionstothefieldofneurotransmittersbyjapanesescientistsandreflectionsonmyownresearch |