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Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research

Part I describes important contributions made by some Japanese pioneers in the field of neurotransmitters: (their achievements in parentheses) J. Takamine (isolation and crystallization of adrenaline); K. Shimidzu (early hint for acetylcholine as a neurotransmitter); F. Kanematsu (donation of the Ka...

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Autor principal: Otsuka, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756739/
https://www.ncbi.nlm.nih.gov/pubmed/24019584
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author Otsuka, Masanori
author_facet Otsuka, Masanori
author_sort Otsuka, Masanori
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description Part I describes important contributions made by some Japanese pioneers in the field of neurotransmitters: (their achievements in parentheses) J. Takamine (isolation and crystallization of adrenaline); K. Shimidzu (early hint for acetylcholine as a neurotransmitter); F. Kanematsu (donation of the Kanematsu Memorial Institute in Sydney); T. Hayashi (discovery of the excitatory action of glutamate and the inhibitory action of GABA); and I. Sano (discovery of a high concentration of dopamine in striatum, its reduction in a patient with Parkinson’s disease and the treatment with DOPA). In Part II, I present some of my reflections on my research on neurotransmitters. The work of my colleagues and myself has made some significant contributions to the establishment of neurotransmitter roles played by GABA and substance P, the first amino acid and the first peptide neurotransmitters, respectively. By the early 1960s, 3 substances, i.e., acetylcholine, noradrenaline, and adrenaline, had been established as neurotransmitters. Now the number of neurotransmitters is believed to be as many as 50 or even more mainly due to the inclusion of several amino acids and a large number of peptide transmitters.
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spelling pubmed-37567392013-09-09 Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research Otsuka, Masanori Proc Jpn Acad Ser B Phys Biol Sci Review Part I describes important contributions made by some Japanese pioneers in the field of neurotransmitters: (their achievements in parentheses) J. Takamine (isolation and crystallization of adrenaline); K. Shimidzu (early hint for acetylcholine as a neurotransmitter); F. Kanematsu (donation of the Kanematsu Memorial Institute in Sydney); T. Hayashi (discovery of the excitatory action of glutamate and the inhibitory action of GABA); and I. Sano (discovery of a high concentration of dopamine in striatum, its reduction in a patient with Parkinson’s disease and the treatment with DOPA). In Part II, I present some of my reflections on my research on neurotransmitters. The work of my colleagues and myself has made some significant contributions to the establishment of neurotransmitter roles played by GABA and substance P, the first amino acid and the first peptide neurotransmitters, respectively. By the early 1960s, 3 substances, i.e., acetylcholine, noradrenaline, and adrenaline, had been established as neurotransmitters. Now the number of neurotransmitters is believed to be as many as 50 or even more mainly due to the inclusion of several amino acids and a large number of peptide transmitters. The Japan Academy 2007-03 /pmc/articles/PMC3756739/ /pubmed/24019584 Text en © 2007 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Otsuka, Masanori
Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
title Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
title_full Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
title_fullStr Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
title_full_unstemmed Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
title_short Contributions to the field of neurotransmitters by Japanese scientists, and reflections on my own research
title_sort contributions to the field of neurotransmitters by japanese scientists, and reflections on my own research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756739/
https://www.ncbi.nlm.nih.gov/pubmed/24019584
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