Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53

DNA damage can lead to the induction of cellular senescence. In particular, we showed that exposure to ionizing radiation (IR) leads to the senescence of bone marrow-derived multipotent stromal cells (MSC) and osteoblast-like stromal cells (OB–SC), a phenotype associated with bone loss. The mechanis...

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Detalles Bibliográficos
Autores principales: Despars, Geneviève, Carbonneau, Cynthia L., Bardeau, Pascal, Coutu, Daniel L., Beauséjour, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756945/
https://www.ncbi.nlm.nih.gov/pubmed/24009740
http://dx.doi.org/10.1371/journal.pone.0073206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756945/
https://www.ncbi.nlm.nih.gov/pubmed/24009740
http://dx.doi.org/10.1371/journal.pone.0073206

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