The Conformational Control Inhibitor of Tyrosine Kinases DCC-2036 Is Effective for Imatinib-Resistant Cells Expressing T674I FIP1L1-PDGFRα

The cells expressing the T674I point mutant of FIP1-like-1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRα) in hypereosinophilics syndrome (HES) are resistant to imatinib and some second-generation tyrosine kinase inhibitors (TKIs). There is a desperate need to develop therapy to combat...

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Detalles Bibliográficos
Autores principales: Shen, Yingying, Shi, Xiaoke, Pan, Jingxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756952/
https://www.ncbi.nlm.nih.gov/pubmed/24009732
http://dx.doi.org/10.1371/journal.pone.0073059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756952/
https://www.ncbi.nlm.nih.gov/pubmed/24009732
http://dx.doi.org/10.1371/journal.pone.0073059

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