PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

PHD1 belongs to the family of prolyl-4-hydroxylases (PHDs) that is responsible for posttranslational modification of prolines on specific target proteins. Because PHD activity is sensitive to oxygen levels and certain byproducts of the tricarboxylic acid cycle, PHDs act as sensors of the cell’s meta...

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Detalles Bibliográficos
Autores principales: Moser, Sandra C., Bensaddek, Dalila, Ortmann, Brian, Maure, Jean-Francois, Mudie, Sharon, Blow, J. Julian, Lamond, Angus I., Swedlow, Jason R., Rocha, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757158/
https://www.ncbi.nlm.nih.gov/pubmed/23932902
http://dx.doi.org/10.1016/j.devcel.2013.06.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757158/
https://www.ncbi.nlm.nih.gov/pubmed/23932902
http://dx.doi.org/10.1016/j.devcel.2013.06.014

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