Cargando…
The blood-brain barrier: an engineering perspective
It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a small number of molecules, such as alcohol and caffeine have been found to cross the blood-brain barrier,...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757302/ https://www.ncbi.nlm.nih.gov/pubmed/24009582 http://dx.doi.org/10.3389/fneng.2013.00007 |
_version_ | 1782282188666961920 |
---|---|
author | Wong, Andrew D. Ye, Mao Levy, Amanda F. Rothstein, Jeffrey D. Bergles, Dwight E. Searson, Peter C. |
author_facet | Wong, Andrew D. Ye, Mao Levy, Amanda F. Rothstein, Jeffrey D. Bergles, Dwight E. Searson, Peter C. |
author_sort | Wong, Andrew D. |
collection | PubMed |
description | It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a small number of molecules, such as alcohol and caffeine have been found to cross the blood-brain barrier, and this selective permeability remains the major roadblock to treatment of many central nervous system diseases. At the same time, many central nervous system diseases are associated with disruption of the blood-brain barrier that can lead to changes in permeability, modulation of immune cell transport, and trafficking of pathogens into the brain. Therefore, advances in our understanding of the structure and function of the blood-brain barrier are key to developing effective treatments for a wide range of central nervous system diseases. Over the past 10 years it has become recognized that the blood-brain barrier is a complex, dynamic system that involves biomechanical and biochemical signaling between the vascular system and the brain. Here we reconstruct the structure, function, and transport properties of the blood-brain barrier from an engineering perspective. New insight into the physics of the blood-brain barrier could ultimately lead to clinical advances in the treatment of central nervous system diseases. |
format | Online Article Text |
id | pubmed-3757302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37573022013-09-05 The blood-brain barrier: an engineering perspective Wong, Andrew D. Ye, Mao Levy, Amanda F. Rothstein, Jeffrey D. Bergles, Dwight E. Searson, Peter C. Front Neuroeng Neuroscience It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a small number of molecules, such as alcohol and caffeine have been found to cross the blood-brain barrier, and this selective permeability remains the major roadblock to treatment of many central nervous system diseases. At the same time, many central nervous system diseases are associated with disruption of the blood-brain barrier that can lead to changes in permeability, modulation of immune cell transport, and trafficking of pathogens into the brain. Therefore, advances in our understanding of the structure and function of the blood-brain barrier are key to developing effective treatments for a wide range of central nervous system diseases. Over the past 10 years it has become recognized that the blood-brain barrier is a complex, dynamic system that involves biomechanical and biochemical signaling between the vascular system and the brain. Here we reconstruct the structure, function, and transport properties of the blood-brain barrier from an engineering perspective. New insight into the physics of the blood-brain barrier could ultimately lead to clinical advances in the treatment of central nervous system diseases. Frontiers Media S.A. 2013-08-30 /pmc/articles/PMC3757302/ /pubmed/24009582 http://dx.doi.org/10.3389/fneng.2013.00007 Text en Copyright © 2013 Wong, Ye, Levy, Rothstein, Bergles and Searson. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wong, Andrew D. Ye, Mao Levy, Amanda F. Rothstein, Jeffrey D. Bergles, Dwight E. Searson, Peter C. The blood-brain barrier: an engineering perspective |
title | The blood-brain barrier: an engineering perspective |
title_full | The blood-brain barrier: an engineering perspective |
title_fullStr | The blood-brain barrier: an engineering perspective |
title_full_unstemmed | The blood-brain barrier: an engineering perspective |
title_short | The blood-brain barrier: an engineering perspective |
title_sort | blood-brain barrier: an engineering perspective |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757302/ https://www.ncbi.nlm.nih.gov/pubmed/24009582 http://dx.doi.org/10.3389/fneng.2013.00007 |
work_keys_str_mv | AT wongandrewd thebloodbrainbarrieranengineeringperspective AT yemao thebloodbrainbarrieranengineeringperspective AT levyamandaf thebloodbrainbarrieranengineeringperspective AT rothsteinjeffreyd thebloodbrainbarrieranengineeringperspective AT berglesdwighte thebloodbrainbarrieranengineeringperspective AT searsonpeterc thebloodbrainbarrieranengineeringperspective AT wongandrewd bloodbrainbarrieranengineeringperspective AT yemao bloodbrainbarrieranengineeringperspective AT levyamandaf bloodbrainbarrieranengineeringperspective AT rothsteinjeffreyd bloodbrainbarrieranengineeringperspective AT berglesdwighte bloodbrainbarrieranengineeringperspective AT searsonpeterc bloodbrainbarrieranengineeringperspective |