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Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study

The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet...

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Autores principales: Noris, Patrizia, Klersy, Catherine, Gresele, Paolo, Giona, Fiorina, Giordano, Paola, Minuz, Pietro, Loffredo, Giuseppe, Pecci, Alessandro, Melazzini, Federica, Civaschi, Elisa, Mezzasoma, Annamaria, Piedimonte, Monica, Semeraro, Fabrizio, Veneri, Dino, Menna, Francesco, Ciardelli, Laura, Balduini, Carlo L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757308/
https://www.ncbi.nlm.nih.gov/pubmed/23617394
http://dx.doi.org/10.1111/bjh.12349
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author Noris, Patrizia
Klersy, Catherine
Gresele, Paolo
Giona, Fiorina
Giordano, Paola
Minuz, Pietro
Loffredo, Giuseppe
Pecci, Alessandro
Melazzini, Federica
Civaschi, Elisa
Mezzasoma, Annamaria
Piedimonte, Monica
Semeraro, Fabrizio
Veneri, Dino
Menna, Francesco
Ciardelli, Laura
Balduini, Carlo L
author_facet Noris, Patrizia
Klersy, Catherine
Gresele, Paolo
Giona, Fiorina
Giordano, Paola
Minuz, Pietro
Loffredo, Giuseppe
Pecci, Alessandro
Melazzini, Federica
Civaschi, Elisa
Mezzasoma, Annamaria
Piedimonte, Monica
Semeraro, Fabrizio
Veneri, Dino
Menna, Francesco
Ciardelli, Laura
Balduini, Carlo L
author_sort Noris, Patrizia
collection PubMed
description The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet volume (MPV) and mean platelet diameter (MPD) with good diagnostic accuracy in this respect. To validate these cut-off values in a different and larger case series of patients, we enrolled 130 subjects with ITP and 113 with IT in six different centres. The platelet count and MPV was each measured by the instrument routinely used in each institution. In some centres, platelet count was also measured by optical microscopy. MPD was evaluated centrally by image analysis of peripheral blood films. The previously identified cut-off value for MPV had 91% specificity in distinguishing ITP from inherited macrothrombocytopenias (mono and biallelic Bernard-Soulier, MYH9-related disease), while its sensitivity was greatly variable depending on the instrument used. With an appropriate instrument, specificity was 83%. The diagnostic accuracy of MPD was lower than that obtained with MPV. We concluded that MPV is a useful parameter for differentiating ITP from IT provided that it is measured by appropriate cell counters.
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spelling pubmed-37573082013-09-04 Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study Noris, Patrizia Klersy, Catherine Gresele, Paolo Giona, Fiorina Giordano, Paola Minuz, Pietro Loffredo, Giuseppe Pecci, Alessandro Melazzini, Federica Civaschi, Elisa Mezzasoma, Annamaria Piedimonte, Monica Semeraro, Fabrizio Veneri, Dino Menna, Francesco Ciardelli, Laura Balduini, Carlo L Br J Haematol Platelets, Haemostasis and Thrombosis The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet volume (MPV) and mean platelet diameter (MPD) with good diagnostic accuracy in this respect. To validate these cut-off values in a different and larger case series of patients, we enrolled 130 subjects with ITP and 113 with IT in six different centres. The platelet count and MPV was each measured by the instrument routinely used in each institution. In some centres, platelet count was also measured by optical microscopy. MPD was evaluated centrally by image analysis of peripheral blood films. The previously identified cut-off value for MPV had 91% specificity in distinguishing ITP from inherited macrothrombocytopenias (mono and biallelic Bernard-Soulier, MYH9-related disease), while its sensitivity was greatly variable depending on the instrument used. With an appropriate instrument, specificity was 83%. The diagnostic accuracy of MPD was lower than that obtained with MPV. We concluded that MPV is a useful parameter for differentiating ITP from IT provided that it is measured by appropriate cell counters. Blackwell Publishing Ltd 2013-07 2013-04-25 /pmc/articles/PMC3757308/ /pubmed/23617394 http://dx.doi.org/10.1111/bjh.12349 Text en Copyright © 2013 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Platelets, Haemostasis and Thrombosis
Noris, Patrizia
Klersy, Catherine
Gresele, Paolo
Giona, Fiorina
Giordano, Paola
Minuz, Pietro
Loffredo, Giuseppe
Pecci, Alessandro
Melazzini, Federica
Civaschi, Elisa
Mezzasoma, Annamaria
Piedimonte, Monica
Semeraro, Fabrizio
Veneri, Dino
Menna, Francesco
Ciardelli, Laura
Balduini, Carlo L
Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
title Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
title_full Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
title_fullStr Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
title_full_unstemmed Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
title_short Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
title_sort platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
topic Platelets, Haemostasis and Thrombosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757308/
https://www.ncbi.nlm.nih.gov/pubmed/23617394
http://dx.doi.org/10.1111/bjh.12349
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