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Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study
The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757308/ https://www.ncbi.nlm.nih.gov/pubmed/23617394 http://dx.doi.org/10.1111/bjh.12349 |
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author | Noris, Patrizia Klersy, Catherine Gresele, Paolo Giona, Fiorina Giordano, Paola Minuz, Pietro Loffredo, Giuseppe Pecci, Alessandro Melazzini, Federica Civaschi, Elisa Mezzasoma, Annamaria Piedimonte, Monica Semeraro, Fabrizio Veneri, Dino Menna, Francesco Ciardelli, Laura Balduini, Carlo L |
author_facet | Noris, Patrizia Klersy, Catherine Gresele, Paolo Giona, Fiorina Giordano, Paola Minuz, Pietro Loffredo, Giuseppe Pecci, Alessandro Melazzini, Federica Civaschi, Elisa Mezzasoma, Annamaria Piedimonte, Monica Semeraro, Fabrizio Veneri, Dino Menna, Francesco Ciardelli, Laura Balduini, Carlo L |
author_sort | Noris, Patrizia |
collection | PubMed |
description | The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet volume (MPV) and mean platelet diameter (MPD) with good diagnostic accuracy in this respect. To validate these cut-off values in a different and larger case series of patients, we enrolled 130 subjects with ITP and 113 with IT in six different centres. The platelet count and MPV was each measured by the instrument routinely used in each institution. In some centres, platelet count was also measured by optical microscopy. MPD was evaluated centrally by image analysis of peripheral blood films. The previously identified cut-off value for MPV had 91% specificity in distinguishing ITP from inherited macrothrombocytopenias (mono and biallelic Bernard-Soulier, MYH9-related disease), while its sensitivity was greatly variable depending on the instrument used. With an appropriate instrument, specificity was 83%. The diagnostic accuracy of MPD was lower than that obtained with MPV. We concluded that MPV is a useful parameter for differentiating ITP from IT provided that it is measured by appropriate cell counters. |
format | Online Article Text |
id | pubmed-3757308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37573082013-09-04 Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study Noris, Patrizia Klersy, Catherine Gresele, Paolo Giona, Fiorina Giordano, Paola Minuz, Pietro Loffredo, Giuseppe Pecci, Alessandro Melazzini, Federica Civaschi, Elisa Mezzasoma, Annamaria Piedimonte, Monica Semeraro, Fabrizio Veneri, Dino Menna, Francesco Ciardelli, Laura Balduini, Carlo L Br J Haematol Platelets, Haemostasis and Thrombosis The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet volume (MPV) and mean platelet diameter (MPD) with good diagnostic accuracy in this respect. To validate these cut-off values in a different and larger case series of patients, we enrolled 130 subjects with ITP and 113 with IT in six different centres. The platelet count and MPV was each measured by the instrument routinely used in each institution. In some centres, platelet count was also measured by optical microscopy. MPD was evaluated centrally by image analysis of peripheral blood films. The previously identified cut-off value for MPV had 91% specificity in distinguishing ITP from inherited macrothrombocytopenias (mono and biallelic Bernard-Soulier, MYH9-related disease), while its sensitivity was greatly variable depending on the instrument used. With an appropriate instrument, specificity was 83%. The diagnostic accuracy of MPD was lower than that obtained with MPV. We concluded that MPV is a useful parameter for differentiating ITP from IT provided that it is measured by appropriate cell counters. Blackwell Publishing Ltd 2013-07 2013-04-25 /pmc/articles/PMC3757308/ /pubmed/23617394 http://dx.doi.org/10.1111/bjh.12349 Text en Copyright © 2013 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Platelets, Haemostasis and Thrombosis Noris, Patrizia Klersy, Catherine Gresele, Paolo Giona, Fiorina Giordano, Paola Minuz, Pietro Loffredo, Giuseppe Pecci, Alessandro Melazzini, Federica Civaschi, Elisa Mezzasoma, Annamaria Piedimonte, Monica Semeraro, Fabrizio Veneri, Dino Menna, Francesco Ciardelli, Laura Balduini, Carlo L Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
title | Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
title_full | Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
title_fullStr | Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
title_full_unstemmed | Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
title_short | Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
title_sort | platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study |
topic | Platelets, Haemostasis and Thrombosis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757308/ https://www.ncbi.nlm.nih.gov/pubmed/23617394 http://dx.doi.org/10.1111/bjh.12349 |
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