BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas

We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypom...

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Autores principales: Lana, Erica, Brun, Marie-Elisabeth, Rivals, Isabelle, Selves, Janick, Kirzin, Sylvain, Lutsyk, Andriy P., Gordiyuk, Vasily V., Bibeau, Frédéric, Rynditch, Alla, De Sario, Albertina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757347/
https://www.ncbi.nlm.nih.gov/pubmed/24280968
http://dx.doi.org/10.3390/cancers1010003
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author Lana, Erica
Brun, Marie-Elisabeth
Rivals, Isabelle
Selves, Janick
Kirzin, Sylvain
Lutsyk, Andriy P.
Gordiyuk, Vasily V.
Bibeau, Frédéric
Rynditch, Alla
De Sario, Albertina
author_facet Lana, Erica
Brun, Marie-Elisabeth
Rivals, Isabelle
Selves, Janick
Kirzin, Sylvain
Lutsyk, Andriy P.
Gordiyuk, Vasily V.
Bibeau, Frédéric
Rynditch, Alla
De Sario, Albertina
author_sort Lana, Erica
collection PubMed
description We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.
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spelling pubmed-37573472013-09-04 BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas Lana, Erica Brun, Marie-Elisabeth Rivals, Isabelle Selves, Janick Kirzin, Sylvain Lutsyk, Andriy P. Gordiyuk, Vasily V. Bibeau, Frédéric Rynditch, Alla De Sario, Albertina Cancers (Basel) Article We showed earlier that BAGE (B melanoma antigen) loci are hypermethylated in normal tissues and hypomethylated in 98% of human cancers. More recently, we provided evidence that hypomethylation of BAGE loci represents an informative marker for colon cancer detection. In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas. Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers. Molecular Diversity Preservation International 2009-11-18 /pmc/articles/PMC3757347/ /pubmed/24280968 http://dx.doi.org/10.3390/cancers1010003 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lana, Erica
Brun, Marie-Elisabeth
Rivals, Isabelle
Selves, Janick
Kirzin, Sylvain
Lutsyk, Andriy P.
Gordiyuk, Vasily V.
Bibeau, Frédéric
Rynditch, Alla
De Sario, Albertina
BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
title BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
title_full BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
title_fullStr BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
title_full_unstemmed BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
title_short BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas
title_sort bage hypomethylation is an early event in colon transformation and is frequent in histologically advanced adenomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757347/
https://www.ncbi.nlm.nih.gov/pubmed/24280968
http://dx.doi.org/10.3390/cancers1010003
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