Acoustic-like dynamics of amorphous drugs in the THz regime

The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic x-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity...

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Detalles Bibliográficos
Autores principales: Pogna, E. A. A., Rodríguez-Tinoco, C., Krisch, M., Rodríguez-Viejo, J., Scopigno, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757359/
https://www.ncbi.nlm.nih.gov/pubmed/23989304
http://dx.doi.org/10.1038/srep02518
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author Pogna, E. A. A.
Rodríguez-Tinoco, C.
Krisch, M.
Rodríguez-Viejo, J.
Scopigno, T.
author_facet Pogna, E. A. A.
Rodríguez-Tinoco, C.
Krisch, M.
Rodríguez-Viejo, J.
Scopigno, T.
author_sort Pogna, E. A. A.
collection PubMed
description The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic x-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.
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spelling pubmed-37573592013-09-03 Acoustic-like dynamics of amorphous drugs in the THz regime Pogna, E. A. A. Rodríguez-Tinoco, C. Krisch, M. Rodríguez-Viejo, J. Scopigno, T. Sci Rep Article The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic x-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively. Nature Publishing Group 2013-08-30 /pmc/articles/PMC3757359/ /pubmed/23989304 http://dx.doi.org/10.1038/srep02518 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Article
Pogna, E. A. A.
Rodríguez-Tinoco, C.
Krisch, M.
Rodríguez-Viejo, J.
Scopigno, T.
Acoustic-like dynamics of amorphous drugs in the THz regime
title Acoustic-like dynamics of amorphous drugs in the THz regime
title_full Acoustic-like dynamics of amorphous drugs in the THz regime
title_fullStr Acoustic-like dynamics of amorphous drugs in the THz regime
title_full_unstemmed Acoustic-like dynamics of amorphous drugs in the THz regime
title_short Acoustic-like dynamics of amorphous drugs in the THz regime
title_sort acoustic-like dynamics of amorphous drugs in the thz regime
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757359/
https://www.ncbi.nlm.nih.gov/pubmed/23989304
http://dx.doi.org/10.1038/srep02518
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