Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach

It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathol...

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Detalles Bibliográficos
Autores principales: Kulendran, Myutan, Stebbing, John F., Marks, Christopher G., Rockall, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757382/
https://www.ncbi.nlm.nih.gov/pubmed/24212777
http://dx.doi.org/10.3390/cancers3021622
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author Kulendran, Myutan
Stebbing, John F.
Marks, Christopher G.
Rockall, Timothy A.
author_facet Kulendran, Myutan
Stebbing, John F.
Marks, Christopher G.
Rockall, Timothy A.
author_sort Kulendran, Myutan
collection PubMed
description It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.
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spelling pubmed-37573822013-09-04 Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach Kulendran, Myutan Stebbing, John F. Marks, Christopher G. Rockall, Timothy A. Cancers (Basel) Review It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β. Molecular Diversity Preservation International (MDPI) 2011-03-29 /pmc/articles/PMC3757382/ /pubmed/24212777 http://dx.doi.org/10.3390/cancers3021622 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kulendran, Myutan
Stebbing, John F.
Marks, Christopher G.
Rockall, Timothy A.
Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
title Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
title_full Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
title_fullStr Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
title_full_unstemmed Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
title_short Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach
title_sort predictive and prognostic factors in colorectal cancer: a personalized approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757382/
https://www.ncbi.nlm.nih.gov/pubmed/24212777
http://dx.doi.org/10.3390/cancers3021622
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AT rockalltimothya predictiveandprognosticfactorsincolorectalcancerapersonalizedapproach

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