Apoptosis and DNA Methylation

Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with main...

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Autores principales: Meng, Huan X., Hackett, James A., Nestor, Colm, Dunican, Donncha S., Madej, Monika, Reddington, James P., Pennings, Sari, Harrison, David J., Meehan, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757391/
https://www.ncbi.nlm.nih.gov/pubmed/24212783
http://dx.doi.org/10.3390/cancers3021798
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author Meng, Huan X.
Hackett, James A.
Nestor, Colm
Dunican, Donncha S.
Madej, Monika
Reddington, James P.
Pennings, Sari
Harrison, David J.
Meehan, Richard R.
author_facet Meng, Huan X.
Hackett, James A.
Nestor, Colm
Dunican, Donncha S.
Madej, Monika
Reddington, James P.
Pennings, Sari
Harrison, David J.
Meehan, Richard R.
author_sort Meng, Huan X.
collection PubMed
description Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
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spelling pubmed-37573912013-09-04 Apoptosis and DNA Methylation Meng, Huan X. Hackett, James A. Nestor, Colm Dunican, Donncha S. Madej, Monika Reddington, James P. Pennings, Sari Harrison, David J. Meehan, Richard R. Cancers (Basel) Review Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG. Molecular Diversity Preservation International (MDPI) 2011-04-01 /pmc/articles/PMC3757391/ /pubmed/24212783 http://dx.doi.org/10.3390/cancers3021798 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Meng, Huan X.
Hackett, James A.
Nestor, Colm
Dunican, Donncha S.
Madej, Monika
Reddington, James P.
Pennings, Sari
Harrison, David J.
Meehan, Richard R.
Apoptosis and DNA Methylation
title Apoptosis and DNA Methylation
title_full Apoptosis and DNA Methylation
title_fullStr Apoptosis and DNA Methylation
title_full_unstemmed Apoptosis and DNA Methylation
title_short Apoptosis and DNA Methylation
title_sort apoptosis and dna methylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757391/
https://www.ncbi.nlm.nih.gov/pubmed/24212783
http://dx.doi.org/10.3390/cancers3021798
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AT reddingtonjamesp apoptosisanddnamethylation
AT penningssari apoptosisanddnamethylation
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