Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

The epidermal growth factor receptor (EGFR) is overexpressed or mutated in glioma. Recently, a series of missense mutations in the extracellular domain (ECD) of EGFR were reported in glioma patients. Some of these mutations clustered within a cysteine-rich region of the EGFR targeted by the therapeu...

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Detalles Bibliográficos
Autores principales: Ymer, Susie I., Greenall, Sameer A., Cvrljevic, Anna, Cao, Diana X., Donoghue, Jacqui F., Epa, V. Chandana, Scott, Andrew M., Adams, Timothy E., Johns, Terrance G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757403/
https://www.ncbi.nlm.nih.gov/pubmed/24212795
http://dx.doi.org/10.3390/cancers3022032

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