X Inactivation and Progenitor Cancer Cells

In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenito...

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Detalles Bibliográficos
Autor principal: Agrelo, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757410/
https://www.ncbi.nlm.nih.gov/pubmed/24212802
http://dx.doi.org/10.3390/cancers3022169
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author Agrelo, Ruben
author_facet Agrelo, Ruben
author_sort Agrelo, Ruben
collection PubMed
description In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.
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spelling pubmed-37574102013-09-04 X Inactivation and Progenitor Cancer Cells Agrelo, Ruben Cancers (Basel) Review In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing. Molecular Diversity Preservation International (MDPI) 2011-04-26 /pmc/articles/PMC3757410/ /pubmed/24212802 http://dx.doi.org/10.3390/cancers3022169 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Agrelo, Ruben
X Inactivation and Progenitor Cancer Cells
title X Inactivation and Progenitor Cancer Cells
title_full X Inactivation and Progenitor Cancer Cells
title_fullStr X Inactivation and Progenitor Cancer Cells
title_full_unstemmed X Inactivation and Progenitor Cancer Cells
title_short X Inactivation and Progenitor Cancer Cells
title_sort x inactivation and progenitor cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757410/
https://www.ncbi.nlm.nih.gov/pubmed/24212802
http://dx.doi.org/10.3390/cancers3022169
work_keys_str_mv AT agreloruben xinactivationandprogenitorcancercells

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