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Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
OBJECTIVE: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos. MATERIALS AND METHODS: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757606/ https://www.ncbi.nlm.nih.gov/pubmed/24014913 http://dx.doi.org/10.4103/0253-7613.115020 |
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author | Kothari, Saroj Kushwah, Anjali Kothari, Dilip |
author_facet | Kothari, Saroj Kushwah, Anjali Kothari, Dilip |
author_sort | Kothari, Saroj |
collection | PubMed |
description | OBJECTIVE: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos. MATERIALS AND METHODS: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in combination with morphine or venlafaxine (subanalgesic) were studied using tail flick test and acetic acid-induced writhing in mice. The effect of pre-treatment with opioid antagonist naltrexone 1mg/kg was also studied on antinociception induced due to ME. RESULT: ME produced a dose-dependent significant antinociceptive activity in the tail flick test and acetic acid-induced writhing in mice. (P<0.05) Administration of subanalgesic dose of ME with morphine or venlafaxine also resulted in significant (P<0.05) antinociceptive activity in both the pain models. Pre-treatment with naltrexone inhibited analgesic activity induced by ME alone and combination with morphine or venlafaxine. CONCLUSION: A.marmelos in induced antinociception is mediated through both opioid and monoaminergic pain pathways, suggest its possible use in chronic pain. |
format | Online Article Text |
id | pubmed-3757606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37576062013-09-06 Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice Kothari, Saroj Kushwah, Anjali Kothari, Dilip Indian J Pharmacol Research Article OBJECTIVE: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos. MATERIALS AND METHODS: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in combination with morphine or venlafaxine (subanalgesic) were studied using tail flick test and acetic acid-induced writhing in mice. The effect of pre-treatment with opioid antagonist naltrexone 1mg/kg was also studied on antinociception induced due to ME. RESULT: ME produced a dose-dependent significant antinociceptive activity in the tail flick test and acetic acid-induced writhing in mice. (P<0.05) Administration of subanalgesic dose of ME with morphine or venlafaxine also resulted in significant (P<0.05) antinociceptive activity in both the pain models. Pre-treatment with naltrexone inhibited analgesic activity induced by ME alone and combination with morphine or venlafaxine. CONCLUSION: A.marmelos in induced antinociception is mediated through both opioid and monoaminergic pain pathways, suggest its possible use in chronic pain. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757606/ /pubmed/24014913 http://dx.doi.org/10.4103/0253-7613.115020 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kothari, Saroj Kushwah, Anjali Kothari, Dilip Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice |
title | Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice |
title_full | Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice |
title_fullStr | Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice |
title_full_unstemmed | Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice |
title_short | Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice |
title_sort | involvement of opioid and monoaminergic pain pathways in aegle marmelos induced analgesia in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757606/ https://www.ncbi.nlm.nih.gov/pubmed/24014913 http://dx.doi.org/10.4103/0253-7613.115020 |
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