Cargando…

Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice

OBJECTIVE: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos. MATERIALS AND METHODS: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kothari, Saroj, Kushwah, Anjali, Kothari, Dilip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757606/
https://www.ncbi.nlm.nih.gov/pubmed/24014913
http://dx.doi.org/10.4103/0253-7613.115020
_version_ 1782282233752584192
author Kothari, Saroj
Kushwah, Anjali
Kothari, Dilip
author_facet Kothari, Saroj
Kushwah, Anjali
Kothari, Dilip
author_sort Kothari, Saroj
collection PubMed
description OBJECTIVE: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos. MATERIALS AND METHODS: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in combination with morphine or venlafaxine (subanalgesic) were studied using tail flick test and acetic acid-induced writhing in mice. The effect of pre-treatment with opioid antagonist naltrexone 1mg/kg was also studied on antinociception induced due to ME. RESULT: ME produced a dose-dependent significant antinociceptive activity in the tail flick test and acetic acid-induced writhing in mice. (P<0.05) Administration of subanalgesic dose of ME with morphine or venlafaxine also resulted in significant (P<0.05) antinociceptive activity in both the pain models. Pre-treatment with naltrexone inhibited analgesic activity induced by ME alone and combination with morphine or venlafaxine. CONCLUSION: A.marmelos in induced antinociception is mediated through both opioid and monoaminergic pain pathways, suggest its possible use in chronic pain.
format Online
Article
Text
id pubmed-3757606
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37576062013-09-06 Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice Kothari, Saroj Kushwah, Anjali Kothari, Dilip Indian J Pharmacol Research Article OBJECTIVE: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos. MATERIALS AND METHODS: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in combination with morphine or venlafaxine (subanalgesic) were studied using tail flick test and acetic acid-induced writhing in mice. The effect of pre-treatment with opioid antagonist naltrexone 1mg/kg was also studied on antinociception induced due to ME. RESULT: ME produced a dose-dependent significant antinociceptive activity in the tail flick test and acetic acid-induced writhing in mice. (P<0.05) Administration of subanalgesic dose of ME with morphine or venlafaxine also resulted in significant (P<0.05) antinociceptive activity in both the pain models. Pre-treatment with naltrexone inhibited analgesic activity induced by ME alone and combination with morphine or venlafaxine. CONCLUSION: A.marmelos in induced antinociception is mediated through both opioid and monoaminergic pain pathways, suggest its possible use in chronic pain. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757606/ /pubmed/24014913 http://dx.doi.org/10.4103/0253-7613.115020 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kothari, Saroj
Kushwah, Anjali
Kothari, Dilip
Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
title Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
title_full Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
title_fullStr Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
title_full_unstemmed Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
title_short Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
title_sort involvement of opioid and monoaminergic pain pathways in aegle marmelos induced analgesia in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757606/
https://www.ncbi.nlm.nih.gov/pubmed/24014913
http://dx.doi.org/10.4103/0253-7613.115020
work_keys_str_mv AT kotharisaroj involvementofopioidandmonoaminergicpainpathwaysinaeglemarmelosinducedanalgesiainmice
AT kushwahanjali involvementofopioidandmonoaminergicpainpathwaysinaeglemarmelosinducedanalgesiainmice
AT kotharidilip involvementofopioidandmonoaminergicpainpathwaysinaeglemarmelosinducedanalgesiainmice