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Terlipressin-induced hyponatremic seizure in a child

Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We...

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Autor principal: Zaki, Syed Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757614/
https://www.ncbi.nlm.nih.gov/pubmed/24014921
http://dx.doi.org/10.4103/0253-7613.114995
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author Zaki, Syed Ahmed
author_facet Zaki, Syed Ahmed
author_sort Zaki, Syed Ahmed
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description Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We describe a 7-year-old male child who developed hyponatremia induced by infusion of terlipressin which resulted in a generalized seizure. After withdrawal of terlipressin, the serum sodium level became normal. Through this case, we emphasize the importance of monitoring patient's electrolyte levels during the course of terlipressin therapy.
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spelling pubmed-37576142013-09-06 Terlipressin-induced hyponatremic seizure in a child Zaki, Syed Ahmed Indian J Pharmacol Drug Watch Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We describe a 7-year-old male child who developed hyponatremia induced by infusion of terlipressin which resulted in a generalized seizure. After withdrawal of terlipressin, the serum sodium level became normal. Through this case, we emphasize the importance of monitoring patient's electrolyte levels during the course of terlipressin therapy. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757614/ /pubmed/24014921 http://dx.doi.org/10.4103/0253-7613.114995 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Zaki, Syed Ahmed
Terlipressin-induced hyponatremic seizure in a child
title Terlipressin-induced hyponatremic seizure in a child
title_full Terlipressin-induced hyponatremic seizure in a child
title_fullStr Terlipressin-induced hyponatremic seizure in a child
title_full_unstemmed Terlipressin-induced hyponatremic seizure in a child
title_short Terlipressin-induced hyponatremic seizure in a child
title_sort terlipressin-induced hyponatremic seizure in a child
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757614/
https://www.ncbi.nlm.nih.gov/pubmed/24014921
http://dx.doi.org/10.4103/0253-7613.114995
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