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Terlipressin-induced hyponatremic seizure in a child
Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757614/ https://www.ncbi.nlm.nih.gov/pubmed/24014921 http://dx.doi.org/10.4103/0253-7613.114995 |
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author | Zaki, Syed Ahmed |
author_facet | Zaki, Syed Ahmed |
author_sort | Zaki, Syed Ahmed |
collection | PubMed |
description | Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We describe a 7-year-old male child who developed hyponatremia induced by infusion of terlipressin which resulted in a generalized seizure. After withdrawal of terlipressin, the serum sodium level became normal. Through this case, we emphasize the importance of monitoring patient's electrolyte levels during the course of terlipressin therapy. |
format | Online Article Text |
id | pubmed-3757614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37576142013-09-06 Terlipressin-induced hyponatremic seizure in a child Zaki, Syed Ahmed Indian J Pharmacol Drug Watch Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We describe a 7-year-old male child who developed hyponatremia induced by infusion of terlipressin which resulted in a generalized seizure. After withdrawal of terlipressin, the serum sodium level became normal. Through this case, we emphasize the importance of monitoring patient's electrolyte levels during the course of terlipressin therapy. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757614/ /pubmed/24014921 http://dx.doi.org/10.4103/0253-7613.114995 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Drug Watch Zaki, Syed Ahmed Terlipressin-induced hyponatremic seizure in a child |
title | Terlipressin-induced hyponatremic seizure in a child |
title_full | Terlipressin-induced hyponatremic seizure in a child |
title_fullStr | Terlipressin-induced hyponatremic seizure in a child |
title_full_unstemmed | Terlipressin-induced hyponatremic seizure in a child |
title_short | Terlipressin-induced hyponatremic seizure in a child |
title_sort | terlipressin-induced hyponatremic seizure in a child |
topic | Drug Watch |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757614/ https://www.ncbi.nlm.nih.gov/pubmed/24014921 http://dx.doi.org/10.4103/0253-7613.114995 |
work_keys_str_mv | AT zakisyedahmed terlipressininducedhyponatremicseizureinachild |