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The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer()
The Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Although cell signaling pathways triggered by the transcription factor Nrf2 prevent cancer initiation and progression in normal and premalignant tissues, in fully malignant cells Nrf2 act...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757665/ https://www.ncbi.nlm.nih.gov/pubmed/24024136 http://dx.doi.org/10.1016/j.redox.2012.10.001 |