Cargando…
Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance()
JS-K is a nitric oxide (NO)-releasing prodrug of the O(2)-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metabolic actions of JS-K was undertaken to investigate...
Autores principales: | Maciag, Anna E., Holland, Ryan J., Robert Cheng, Y.-S., Rodriguez, Luis G., Saavedra, Joseph E., Anderson, Lucy M., Keefer, Larry K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757670/ https://www.ncbi.nlm.nih.gov/pubmed/24024144 http://dx.doi.org/10.1016/j.redox.2012.12.002 |
Ejemplares similares
-
TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells
por: Simeone, Ann-Marie, et al.
Publicado: (2008) -
Nitric Oxide (NO) Releasing
Poly ADP-ribose Polymerase
1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase
P1-Overexpressing Cancer Cells
por: Maciag, Anna E., et al.
Publicado: (2014) -
Direct Reaction of Amides
with Nitric Oxide To Form Diazeniumdiolates
por: Holland, Ryan J., et al.
Publicado: (2014) -
Structure-based design of anticancer prodrug PABA/NO
por: Ji, Xinhua, et al.
Publicado: (2009) -
Hydrolytic Reactivity Trends among Potential Prodrugs of the O(2)-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity
por: Valdez, Carlos A., et al.
Publicado: (2008)