The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()

The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regu...

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Detalles Bibliográficos
Autores principales: Jung, Tobias, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757679/
https://www.ncbi.nlm.nih.gov/pubmed/24024151
http://dx.doi.org/10.1016/j.redox.2013.01.004
Descripción
Sumario:The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the structure of the 20S proteasome as well as its associated regulator proteins.

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