The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()

The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regu...

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Detalles Bibliográficos
Autores principales: Jung, Tobias, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757679/
https://www.ncbi.nlm.nih.gov/pubmed/24024151
http://dx.doi.org/10.1016/j.redox.2013.01.004
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author Jung, Tobias
Grune, Tilman
author_facet Jung, Tobias
Grune, Tilman
author_sort Jung, Tobias
collection PubMed
description The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the structure of the 20S proteasome as well as its associated regulator proteins.
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spelling pubmed-37576792013-09-10 The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes() Jung, Tobias Grune, Tilman Redox Biol Graphical Review The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the structure of the 20S proteasome as well as its associated regulator proteins. Elsevier 2013-01-19 /pmc/articles/PMC3757679/ /pubmed/24024151 http://dx.doi.org/10.1016/j.redox.2013.01.004 Text en © 2013 The Authors http://creativecommons.org/licenses/BY-license/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Graphical Review
Jung, Tobias
Grune, Tilman
The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
title The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
title_full The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
title_fullStr The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
title_full_unstemmed The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
title_short The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes()
title_sort proteasome and the degradation of oxidized proteins: part i—structure of proteasomes()
topic Graphical Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757679/
https://www.ncbi.nlm.nih.gov/pubmed/24024151
http://dx.doi.org/10.1016/j.redox.2013.01.004
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