Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment()

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people carrying the C677T MTHFR polymorphism which...

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Detalles Bibliográficos
Autores principales: Rajagopalan, Priya, Jahanshad, Neda, Stein, Jason L., Hua, Xue, Madsen, Sarah K., Kohannim, Omid, Hibar, Derrek P., Toga, Arthur W., Jack, Clifford R., Saykin, Andrew J., Green, Robert C., Weiner, Michael W., Bis, Joshua C., Kuller, Lewis H., Riverol, Mario, Becker, James T., Lopez, Oscar L., Thompson, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757723/
https://www.ncbi.nlm.nih.gov/pubmed/24179750
http://dx.doi.org/10.1016/j.nicl.2012.09.012

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