DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT

The consequences of DNA damage generation in mammalian somatic stem cells, including neural stem cells (NSCs), are poorly understood despite their potential relevance for tissue homeostasis. Here, we show that, following ionizing radiation-induced DNA damage, NSCs enter irreversible proliferative ar...

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Detalles Bibliográficos
Autores principales: Schneider, Leonid, Pellegatta, Serena, Favaro, Rebecca, Pisati, Federica, Roncaglia, Paola, Testa, Giuseppe, Nicolis, Silvia K., Finocchiaro, Gaetano, d’Adda di Fagagna, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757751/
https://www.ncbi.nlm.nih.gov/pubmed/24052948
http://dx.doi.org/10.1016/j.stemcr.2013.06.004

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