Cargando…

Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia

BACKGROUND: Various adjuncts have been used with lignocaine to decrease tourniquet pain and prolong post-operative analgesia during intravenous regional anesthesia (IVRA). Calcium-channel blockers potentiate the analgesic effect of local anesthetics. This study was designed to evaluate the efficacy...

Descripción completa

Detalles Bibliográficos
Autores principales: Khanna, Puneet, Mohan, Virender Kumar, Sunder, Rani Achanpa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757805/
https://www.ncbi.nlm.nih.gov/pubmed/24015135
http://dx.doi.org/10.4103/1658-354X.115359
_version_ 1782282271937527808
author Khanna, Puneet
Mohan, Virender Kumar
Sunder, Rani Achanpa
author_facet Khanna, Puneet
Mohan, Virender Kumar
Sunder, Rani Achanpa
author_sort Khanna, Puneet
collection PubMed
description BACKGROUND: Various adjuncts have been used with lignocaine to decrease tourniquet pain and prolong post-operative analgesia during intravenous regional anesthesia (IVRA). Calcium-channel blockers potentiate the analgesic effect of local anesthetics. This study was designed to evaluate the efficacy of diltiazem as an adjunct to lignocaine in IVRA with respect to tourniquet tolerance, perioperative analgesia, and quality of anesthesia. METHODS: In this prospective, randomized, and double-blind study, 40 patients (American Society for Anesthesiologists grade I/II) undergoing elective hand surgery under IVRA were assigned into two groups of 20 each and administered IVRA either with lignocaine 3 mg/kg (group Lignocaine (L)) or lignocaine 3 mg/kg plus diltiazem 0.2 mg/kg (group Lignocaine-Diltiazem (LD)) with normal saline (total volume-40 ml). Hemodynamic parameters, onset of the complete sensory blockade, motor blockade, and intraoperative (tourniquet pain) and post-operative Visual Analogue Scale scores, total intraoperative and consumption of post-operative fentanyl intraoperative were recorded. RESULTS: Sensory block was established in 2.5±0.688 min in group LD verses 5.60±0.851 min in group L. Motor blockade was established in 8.65±0.933 min in group LD and 13.46±0.604 min in group L. The mean VAS scores >3 were attained early at 30 min (3.1±0.912) in group L. Patients in group L requested early rescue analgesic at 30±8.633 min compared with 49.64±7.958 min in group LD. CONCLUSIONS: Diltiazem as an adjunct to lignocaine provided enhanced intraoperative and post-operative analgesia without any significant side effects.
format Online
Article
Text
id pubmed-3757805
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37578052013-09-06 Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia Khanna, Puneet Mohan, Virender Kumar Sunder, Rani Achanpa Saudi J Anaesth Original Article BACKGROUND: Various adjuncts have been used with lignocaine to decrease tourniquet pain and prolong post-operative analgesia during intravenous regional anesthesia (IVRA). Calcium-channel blockers potentiate the analgesic effect of local anesthetics. This study was designed to evaluate the efficacy of diltiazem as an adjunct to lignocaine in IVRA with respect to tourniquet tolerance, perioperative analgesia, and quality of anesthesia. METHODS: In this prospective, randomized, and double-blind study, 40 patients (American Society for Anesthesiologists grade I/II) undergoing elective hand surgery under IVRA were assigned into two groups of 20 each and administered IVRA either with lignocaine 3 mg/kg (group Lignocaine (L)) or lignocaine 3 mg/kg plus diltiazem 0.2 mg/kg (group Lignocaine-Diltiazem (LD)) with normal saline (total volume-40 ml). Hemodynamic parameters, onset of the complete sensory blockade, motor blockade, and intraoperative (tourniquet pain) and post-operative Visual Analogue Scale scores, total intraoperative and consumption of post-operative fentanyl intraoperative were recorded. RESULTS: Sensory block was established in 2.5±0.688 min in group LD verses 5.60±0.851 min in group L. Motor blockade was established in 8.65±0.933 min in group LD and 13.46±0.604 min in group L. The mean VAS scores >3 were attained early at 30 min (3.1±0.912) in group L. Patients in group L requested early rescue analgesic at 30±8.633 min compared with 49.64±7.958 min in group LD. CONCLUSIONS: Diltiazem as an adjunct to lignocaine provided enhanced intraoperative and post-operative analgesia without any significant side effects. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757805/ /pubmed/24015135 http://dx.doi.org/10.4103/1658-354X.115359 Text en Copyright: © Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khanna, Puneet
Mohan, Virender Kumar
Sunder, Rani Achanpa
Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
title Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
title_full Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
title_fullStr Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
title_full_unstemmed Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
title_short Efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
title_sort efficacy of diltiazem as an adjunct to lignocaine in intravenous regional anesthesia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757805/
https://www.ncbi.nlm.nih.gov/pubmed/24015135
http://dx.doi.org/10.4103/1658-354X.115359
work_keys_str_mv AT khannapuneet efficacyofdiltiazemasanadjuncttolignocaineinintravenousregionalanesthesia
AT mohanvirenderkumar efficacyofdiltiazemasanadjuncttolignocaineinintravenousregionalanesthesia
AT sunderraniachanpa efficacyofdiltiazemasanadjuncttolignocaineinintravenousregionalanesthesia