Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique

A rapid, nondestructive Raman spectroscopic method was developed for quantitative estimation of paracetamol and nimesulide in their combined dosage form. A Raman univariate calibration model was developed by measuring the peak intensities of paracetamol and nimesulide at 853 cm(−1) and 1336 cm(−1),...

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Autores principales: Lakhwani, Gargi R., Sherikar, O. D., Mehta, Priti J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757861/
https://www.ncbi.nlm.nih.gov/pubmed/24019571
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author Lakhwani, Gargi R.
Sherikar, O. D.
Mehta, Priti J.
author_facet Lakhwani, Gargi R.
Sherikar, O. D.
Mehta, Priti J.
author_sort Lakhwani, Gargi R.
collection PubMed
description A rapid, nondestructive Raman spectroscopic method was developed for quantitative estimation of paracetamol and nimesulide in their combined dosage form. A Raman univariate calibration model was developed by measuring the peak intensities of paracetamol and nimesulide at 853 cm(−1) and 1336 cm(−1), respectively. The developed method was successfully applied for in situ, concurrent estimation of paracetamol and nimesulide in their combined dosage and method was also validated according to International Conference on Harmonisation guidelines. Thus, the developed Raman spectroscopic method can be applied for simultaneous estimation of paracetamol and nimesulide in their combined dosage form as a process analytical technology tool by pharmaceutical industries for routine quality control.
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spelling pubmed-37578612013-09-09 Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique Lakhwani, Gargi R. Sherikar, O. D. Mehta, Priti J. Indian J Pharm Sci Research Paper A rapid, nondestructive Raman spectroscopic method was developed for quantitative estimation of paracetamol and nimesulide in their combined dosage form. A Raman univariate calibration model was developed by measuring the peak intensities of paracetamol and nimesulide at 853 cm(−1) and 1336 cm(−1), respectively. The developed method was successfully applied for in situ, concurrent estimation of paracetamol and nimesulide in their combined dosage and method was also validated according to International Conference on Harmonisation guidelines. Thus, the developed Raman spectroscopic method can be applied for simultaneous estimation of paracetamol and nimesulide in their combined dosage form as a process analytical technology tool by pharmaceutical industries for routine quality control. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757861/ /pubmed/24019571 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Lakhwani, Gargi R.
Sherikar, O. D.
Mehta, Priti J.
Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique
title Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique
title_full Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique
title_fullStr Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique
title_full_unstemmed Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique
title_short Nondestructive and Rapid Concurrent Estimation of Paracetamol and Nimesulide in Their Combined Dosage Form Using Raman Spectroscopic Technique
title_sort nondestructive and rapid concurrent estimation of paracetamol and nimesulide in their combined dosage form using raman spectroscopic technique
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757861/
https://www.ncbi.nlm.nih.gov/pubmed/24019571
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