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Oral buccoadhesive films of ondansetron: Development and evaluation
INTRODUCTION: Difficulty or inability in swallowing tablets/capsules during or after chemotherapy is common due to chemotherapy induced nausea and vomiting in patients. Buccoadhesive films of ondansetron hydrochloride were prepared for the prevention and treatment of chemotherapy-induced emesis. Fil...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757901/ https://www.ncbi.nlm.nih.gov/pubmed/24015383 http://dx.doi.org/10.4103/2230-973X.114894 |
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author | Kumria, Rachna Gupta, Vishant Bansal, Sanjay Wadhwa, Jyoti Nair, Anroop B |
author_facet | Kumria, Rachna Gupta, Vishant Bansal, Sanjay Wadhwa, Jyoti Nair, Anroop B |
author_sort | Kumria, Rachna |
collection | PubMed |
description | INTRODUCTION: Difficulty or inability in swallowing tablets/capsules during or after chemotherapy is common due to chemotherapy induced nausea and vomiting in patients. Buccoadhesive films of ondansetron hydrochloride were prepared for the prevention and treatment of chemotherapy-induced emesis. Films of varying polymeric composition were prepared in order to facilitate initial as well as prolonged drug release that could take care of acute as well as delayed emesis. MATERIALS AND METHODS: Mucoadhesive films were prepared using polymers such as hydroxypropyl methylcellulose (HPMC) E5, HPMC K100, and Eudragit(®) NE 30 D. The effect of concentration of these polymers on physical properties and drug release were studied. All the films were prepared by solvent casting method. In another part of the study, the effect of drug concentration on physical and mucoadhesive properties of film were assessed, keeping the polymer concentration fixed. RESULTS: Films containing HPMC showed good mucoadhesion. Increasing the concentration of Eudragit(®) NE 30 D in the films retarded drug release and increased residence time, however, reduced mucoadhesion. At a fixed polymer concentration and ratio, films prepared using an increased drug content showed an increased mucoadhesion. CONCLUSION: Films prepared using HPMC E5 (1000 mg), HPMC K100 (500 mg), and Eudragit(®) NE 30 D (750 mg) provided initial rapid followed by sustained drug release over a period of 6 h. Given the promising results, the study concluded that the developed buccal films have the potential to release ondansetron required for chemotherapy induced acute and delayed emesis. |
format | Online Article Text |
id | pubmed-3757901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37579012013-09-06 Oral buccoadhesive films of ondansetron: Development and evaluation Kumria, Rachna Gupta, Vishant Bansal, Sanjay Wadhwa, Jyoti Nair, Anroop B Int J Pharm Investig Original Research Article INTRODUCTION: Difficulty or inability in swallowing tablets/capsules during or after chemotherapy is common due to chemotherapy induced nausea and vomiting in patients. Buccoadhesive films of ondansetron hydrochloride were prepared for the prevention and treatment of chemotherapy-induced emesis. Films of varying polymeric composition were prepared in order to facilitate initial as well as prolonged drug release that could take care of acute as well as delayed emesis. MATERIALS AND METHODS: Mucoadhesive films were prepared using polymers such as hydroxypropyl methylcellulose (HPMC) E5, HPMC K100, and Eudragit(®) NE 30 D. The effect of concentration of these polymers on physical properties and drug release were studied. All the films were prepared by solvent casting method. In another part of the study, the effect of drug concentration on physical and mucoadhesive properties of film were assessed, keeping the polymer concentration fixed. RESULTS: Films containing HPMC showed good mucoadhesion. Increasing the concentration of Eudragit(®) NE 30 D in the films retarded drug release and increased residence time, however, reduced mucoadhesion. At a fixed polymer concentration and ratio, films prepared using an increased drug content showed an increased mucoadhesion. CONCLUSION: Films prepared using HPMC E5 (1000 mg), HPMC K100 (500 mg), and Eudragit(®) NE 30 D (750 mg) provided initial rapid followed by sustained drug release over a period of 6 h. Given the promising results, the study concluded that the developed buccal films have the potential to release ondansetron required for chemotherapy induced acute and delayed emesis. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757901/ /pubmed/24015383 http://dx.doi.org/10.4103/2230-973X.114894 Text en Copyright: © International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Kumria, Rachna Gupta, Vishant Bansal, Sanjay Wadhwa, Jyoti Nair, Anroop B Oral buccoadhesive films of ondansetron: Development and evaluation |
title | Oral buccoadhesive films of ondansetron: Development and evaluation |
title_full | Oral buccoadhesive films of ondansetron: Development and evaluation |
title_fullStr | Oral buccoadhesive films of ondansetron: Development and evaluation |
title_full_unstemmed | Oral buccoadhesive films of ondansetron: Development and evaluation |
title_short | Oral buccoadhesive films of ondansetron: Development and evaluation |
title_sort | oral buccoadhesive films of ondansetron: development and evaluation |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757901/ https://www.ncbi.nlm.nih.gov/pubmed/24015383 http://dx.doi.org/10.4103/2230-973X.114894 |
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