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Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release

OBJECTIVE: Current research was aimed at the development of the drug delivery systems based on the superporous hydrogels (SPH) with the desired swelling and the mechanical properties. MATERIALS AND METHODS: Superporous hydrogel composites (SPHCs) and superporous hybrid hydrogels (SPHHs) based on the...

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Autores principales: Nagpal, Manju, Singh, Shailendra Kumar, Mishra, Dinanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757904/
https://www.ncbi.nlm.nih.gov/pubmed/24015380
http://dx.doi.org/10.4103/2230-973X.114906
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author Nagpal, Manju
Singh, Shailendra Kumar
Mishra, Dinanath
author_facet Nagpal, Manju
Singh, Shailendra Kumar
Mishra, Dinanath
author_sort Nagpal, Manju
collection PubMed
description OBJECTIVE: Current research was aimed at the development of the drug delivery systems based on the superporous hydrogels (SPH) with the desired swelling and the mechanical properties. MATERIALS AND METHODS: Superporous hydrogel composites (SPHCs) and superporous hybrid hydrogels (SPHHs) based on the chitosan and the polyacrylamide were synthesized using the gas blowing technique. The prepared hydrogels were evaluated for swelling studies, mechanical strength and scanning electron microscopy. The selected hydrogels were loaded with the drug (verapamil hydrochloride) by aqueous loading method. Drug integrity with in polymeric network was evaluated via fourier transform infrared spectroscopy (FTIR), X-ray diffraction (X-RD), differential scanning calorimetry (DSC), proton nuclear magnetic resonance ((1)HNMR) studies. In vitro drug release studies were carried out using the united state pharmacopoeial (USP) dissolution apparatus (type II). RESULTS AND DISCUSSION: The mechanical strength was observed to be higher in SPH hybrids in comparison to that in SPHCs while no significant difference was observed in swelling behavior. In situ crosslinking of chitosan with glutaraldehyde (GA) may be responsible for high mechanical strength. The equilibrium swelling time was slight higher in SPHH than in SPHCs. The integrity of pores was maintained in ethanol treated hydrogels as observed in scanning electron micrographs. Whereas, freeze dried SPH samples showed non-uniform pores. No drug polymer interaction was observed as indicated by DSC, FTIR, X-RD and NMR studies. However, the crosslinking of chitosan with GA was clearly indicated by these studies. The in vitro drug release studies from SPH hybrids indicated initial fast release (65%) with in first 2 h and then sustained release at the end of 24 h (95%). The addition of hydroxypropyl methyl cellulose with drug; however, leads to a significant decrease in drug release (56% at the end of 24 h). CONCLUSION: Superporous hybrid hydrogels can be promising devices for the sustained delivery of drug candidates to the gastrointestinal region.
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spelling pubmed-37579042013-09-06 Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release Nagpal, Manju Singh, Shailendra Kumar Mishra, Dinanath Int J Pharm Investig Original Research Article OBJECTIVE: Current research was aimed at the development of the drug delivery systems based on the superporous hydrogels (SPH) with the desired swelling and the mechanical properties. MATERIALS AND METHODS: Superporous hydrogel composites (SPHCs) and superporous hybrid hydrogels (SPHHs) based on the chitosan and the polyacrylamide were synthesized using the gas blowing technique. The prepared hydrogels were evaluated for swelling studies, mechanical strength and scanning electron microscopy. The selected hydrogels were loaded with the drug (verapamil hydrochloride) by aqueous loading method. Drug integrity with in polymeric network was evaluated via fourier transform infrared spectroscopy (FTIR), X-ray diffraction (X-RD), differential scanning calorimetry (DSC), proton nuclear magnetic resonance ((1)HNMR) studies. In vitro drug release studies were carried out using the united state pharmacopoeial (USP) dissolution apparatus (type II). RESULTS AND DISCUSSION: The mechanical strength was observed to be higher in SPH hybrids in comparison to that in SPHCs while no significant difference was observed in swelling behavior. In situ crosslinking of chitosan with glutaraldehyde (GA) may be responsible for high mechanical strength. The equilibrium swelling time was slight higher in SPHH than in SPHCs. The integrity of pores was maintained in ethanol treated hydrogels as observed in scanning electron micrographs. Whereas, freeze dried SPH samples showed non-uniform pores. No drug polymer interaction was observed as indicated by DSC, FTIR, X-RD and NMR studies. However, the crosslinking of chitosan with GA was clearly indicated by these studies. The in vitro drug release studies from SPH hybrids indicated initial fast release (65%) with in first 2 h and then sustained release at the end of 24 h (95%). The addition of hydroxypropyl methyl cellulose with drug; however, leads to a significant decrease in drug release (56% at the end of 24 h). CONCLUSION: Superporous hybrid hydrogels can be promising devices for the sustained delivery of drug candidates to the gastrointestinal region. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757904/ /pubmed/24015380 http://dx.doi.org/10.4103/2230-973X.114906 Text en Copyright: © International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Nagpal, Manju
Singh, Shailendra Kumar
Mishra, Dinanath
Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release
title Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release
title_full Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release
title_fullStr Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release
title_full_unstemmed Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release
title_short Superporous hybrid hydrogels based on polyacrylamide and chitosan: Characterization and in vitro drug release
title_sort superporous hybrid hydrogels based on polyacrylamide and chitosan: characterization and in vitro drug release
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757904/
https://www.ncbi.nlm.nih.gov/pubmed/24015380
http://dx.doi.org/10.4103/2230-973X.114906
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