A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report

Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the Wor...

Descripción completa

Detalles Bibliográficos
Autores principales: Appachu, Sandhya, Obulareddy, Chintaparthi, Sirsath, Nagesh T, Lakshmaiah, Kuntejowdahalli C, Kumari, Prasanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757957/
https://www.ncbi.nlm.nih.gov/pubmed/24009642
http://dx.doi.org/10.3332/ecancer.2013.340
_version_ 1782282299995324416
author Appachu, Sandhya
Obulareddy, Chintaparthi
Sirsath, Nagesh T
Lakshmaiah, Kuntejowdahalli C
Kumari, Prasanna
author_facet Appachu, Sandhya
Obulareddy, Chintaparthi
Sirsath, Nagesh T
Lakshmaiah, Kuntejowdahalli C
Kumari, Prasanna
author_sort Appachu, Sandhya
collection PubMed
description Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system. It is one of the curable malignancies, has a unique clinical presentation, often with disseminated intravascular coagulation, and has a targeted therapy for its treatment in the form of all trans retinoic acid (ATRA) and arsenic trioxide (ATO). Here, we report a complex type of variant APML t(3;15) (q26;q13), the need for conventional karyotyping for diagnosing such rare variants, and its response to ATRA and ATO.
format Online
Article
Text
id pubmed-3757957
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Cancer Intelligence
record_format MEDLINE/PubMed
spelling pubmed-37579572013-09-04 A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report Appachu, Sandhya Obulareddy, Chintaparthi Sirsath, Nagesh T Lakshmaiah, Kuntejowdahalli C Kumari, Prasanna Ecancermedicalscience Case Report Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system. It is one of the curable malignancies, has a unique clinical presentation, often with disseminated intravascular coagulation, and has a targeted therapy for its treatment in the form of all trans retinoic acid (ATRA) and arsenic trioxide (ATO). Here, we report a complex type of variant APML t(3;15) (q26;q13), the need for conventional karyotyping for diagnosing such rare variants, and its response to ATRA and ATO. Cancer Intelligence 2013-08-15 /pmc/articles/PMC3757957/ /pubmed/24009642 http://dx.doi.org/10.3332/ecancer.2013.340 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Appachu, Sandhya
Obulareddy, Chintaparthi
Sirsath, Nagesh T
Lakshmaiah, Kuntejowdahalli C
Kumari, Prasanna
A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
title A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
title_full A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
title_fullStr A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
title_full_unstemmed A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
title_short A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
title_sort complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15—a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757957/
https://www.ncbi.nlm.nih.gov/pubmed/24009642
http://dx.doi.org/10.3332/ecancer.2013.340
work_keys_str_mv AT appachusandhya acomplexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT obulareddychintaparthi acomplexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT sirsathnagesht acomplexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT lakshmaiahkuntejowdahallic acomplexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT kumariprasanna acomplexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT appachusandhya complexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT obulareddychintaparthi complexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT sirsathnagesht complexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT lakshmaiahkuntejowdahallic complexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport
AT kumariprasanna complexvariantt315q26q13representingcrypticmaskedacutepromyelocyticleukaemiawithanovelbreakpointofchromosome15acasereport

Ejemplares similares