Generation of Helper Plasmids Encoding Mutant Adeno-associated Virus Type 2 Capsid Proteins with Increased Resistance against Proteasomal Degradation

Objective(s): Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In...

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Detalles Bibliográficos
Autores principales: Ahmadiankia, Naghmeh, Neshati, Vajiheh, Neshati, Zeinab, Swildens, Jim, AF de Vries, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758051/
https://www.ncbi.nlm.nih.gov/pubmed/23997910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758051/
https://www.ncbi.nlm.nih.gov/pubmed/23997910

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