Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
BACKGROUND: Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. OBJECTIVE: The purpose...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758269/ https://www.ncbi.nlm.nih.gov/pubmed/24023698 http://dx.doi.org/10.1371/journal.pone.0074215 |
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author | Cahill, Farrell Amini, Peyvand Wadden, Danny Khalili, Sammy Randell, Edward Vasdev, Sudesh Gulliver, Wayne Sun, Guang |
author_facet | Cahill, Farrell Amini, Peyvand Wadden, Danny Khalili, Sammy Randell, Edward Vasdev, Sudesh Gulliver, Wayne Sun, Guang |
author_sort | Cahill, Farrell |
collection | PubMed |
description | BACKGROUND: Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. OBJECTIVE: The purpose of this study was to investigate how circulating adiponectin will respond to a short-term PEC and whether or not this response will differ among normal-weight(NW), overweight(OW) and obese(OB). DESIGN: We examined adiponectin among 64 young men (19-29 yr) before and after a 7-day overfeeding (70% above normal energy requirements). The relationship between adiponectin and obesity related phenotypes including; weight, percent body fat (%BF), percent trunk fat (%TF), percent android fat (%AF), body mass index (BMI), total cholesterol, HDLc, LDLc, glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were analyzed before and after overfeeding. RESULTS: Analysis of variance (ANOVA) and partial correlations were used to compute the effect of overfeeding on adiponectin and its association with adiposity measurements, respectively. Circulating Adiponectin levels significantly increased after the 7-day overfeeding in all three adiposity groups. Moreover, adiponectin at baseline was not significantly different among NW, OW and OB subjects defined by either %BF or BMI. Baseline adiponectin was negatively correlated with weight and BMI for the entire cohort and %TF, glucose, insulin and HOMA-IR in OB. However, after controlling for insulin resistance the correlation of adiponectin with weight, BMI and %TF were nullified. CONCLUSION: Our study provides evidence that the protective response of adiponectin is preserved during a PEC regardless of adiposity. Baseline adiponectin level is not directly associated with obesity status and weight gain in response to short-term overfeeding. However, the significant increase of adiponectin in response to overfeeding indicates the physiological potential for adiponectin to attenuate insulin resistance during the development of obesity. |
format | Online Article Text |
id | pubmed-3758269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37582692013-09-10 Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status Cahill, Farrell Amini, Peyvand Wadden, Danny Khalili, Sammy Randell, Edward Vasdev, Sudesh Gulliver, Wayne Sun, Guang PLoS One Research Article BACKGROUND: Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. OBJECTIVE: The purpose of this study was to investigate how circulating adiponectin will respond to a short-term PEC and whether or not this response will differ among normal-weight(NW), overweight(OW) and obese(OB). DESIGN: We examined adiponectin among 64 young men (19-29 yr) before and after a 7-day overfeeding (70% above normal energy requirements). The relationship between adiponectin and obesity related phenotypes including; weight, percent body fat (%BF), percent trunk fat (%TF), percent android fat (%AF), body mass index (BMI), total cholesterol, HDLc, LDLc, glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were analyzed before and after overfeeding. RESULTS: Analysis of variance (ANOVA) and partial correlations were used to compute the effect of overfeeding on adiponectin and its association with adiposity measurements, respectively. Circulating Adiponectin levels significantly increased after the 7-day overfeeding in all three adiposity groups. Moreover, adiponectin at baseline was not significantly different among NW, OW and OB subjects defined by either %BF or BMI. Baseline adiponectin was negatively correlated with weight and BMI for the entire cohort and %TF, glucose, insulin and HOMA-IR in OB. However, after controlling for insulin resistance the correlation of adiponectin with weight, BMI and %TF were nullified. CONCLUSION: Our study provides evidence that the protective response of adiponectin is preserved during a PEC regardless of adiposity. Baseline adiponectin level is not directly associated with obesity status and weight gain in response to short-term overfeeding. However, the significant increase of adiponectin in response to overfeeding indicates the physiological potential for adiponectin to attenuate insulin resistance during the development of obesity. Public Library of Science 2013-08-30 /pmc/articles/PMC3758269/ /pubmed/24023698 http://dx.doi.org/10.1371/journal.pone.0074215 Text en © 2013 Cahill et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Cahill, Farrell Amini, Peyvand Wadden, Danny Khalili, Sammy Randell, Edward Vasdev, Sudesh Gulliver, Wayne Sun, Guang Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status |
title | Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status |
title_full | Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status |
title_fullStr | Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status |
title_full_unstemmed | Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status |
title_short | Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status |
title_sort | short-term overfeeding increases circulating adiponectin independent of obesity status |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758269/ https://www.ncbi.nlm.nih.gov/pubmed/24023698 http://dx.doi.org/10.1371/journal.pone.0074215 |
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