Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status

BACKGROUND: Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. OBJECTIVE: The purpose...

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Autores principales: Cahill, Farrell, Amini, Peyvand, Wadden, Danny, Khalili, Sammy, Randell, Edward, Vasdev, Sudesh, Gulliver, Wayne, Sun, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758269/
https://www.ncbi.nlm.nih.gov/pubmed/24023698
http://dx.doi.org/10.1371/journal.pone.0074215
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author Cahill, Farrell
Amini, Peyvand
Wadden, Danny
Khalili, Sammy
Randell, Edward
Vasdev, Sudesh
Gulliver, Wayne
Sun, Guang
author_facet Cahill, Farrell
Amini, Peyvand
Wadden, Danny
Khalili, Sammy
Randell, Edward
Vasdev, Sudesh
Gulliver, Wayne
Sun, Guang
author_sort Cahill, Farrell
collection PubMed
description BACKGROUND: Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. OBJECTIVE: The purpose of this study was to investigate how circulating adiponectin will respond to a short-term PEC and whether or not this response will differ among normal-weight(NW), overweight(OW) and obese(OB). DESIGN: We examined adiponectin among 64 young men (19-29 yr) before and after a 7-day overfeeding (70% above normal energy requirements). The relationship between adiponectin and obesity related phenotypes including; weight, percent body fat (%BF), percent trunk fat (%TF), percent android fat (%AF), body mass index (BMI), total cholesterol, HDLc, LDLc, glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were analyzed before and after overfeeding. RESULTS: Analysis of variance (ANOVA) and partial correlations were used to compute the effect of overfeeding on adiponectin and its association with adiposity measurements, respectively. Circulating Adiponectin levels significantly increased after the 7-day overfeeding in all three adiposity groups. Moreover, adiponectin at baseline was not significantly different among NW, OW and OB subjects defined by either %BF or BMI. Baseline adiponectin was negatively correlated with weight and BMI for the entire cohort and %TF, glucose, insulin and HOMA-IR in OB. However, after controlling for insulin resistance the correlation of adiponectin with weight, BMI and %TF were nullified. CONCLUSION: Our study provides evidence that the protective response of adiponectin is preserved during a PEC regardless of adiposity. Baseline adiponectin level is not directly associated with obesity status and weight gain in response to short-term overfeeding. However, the significant increase of adiponectin in response to overfeeding indicates the physiological potential for adiponectin to attenuate insulin resistance during the development of obesity.
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spelling pubmed-37582692013-09-10 Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status Cahill, Farrell Amini, Peyvand Wadden, Danny Khalili, Sammy Randell, Edward Vasdev, Sudesh Gulliver, Wayne Sun, Guang PLoS One Research Article BACKGROUND: Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response. OBJECTIVE: The purpose of this study was to investigate how circulating adiponectin will respond to a short-term PEC and whether or not this response will differ among normal-weight(NW), overweight(OW) and obese(OB). DESIGN: We examined adiponectin among 64 young men (19-29 yr) before and after a 7-day overfeeding (70% above normal energy requirements). The relationship between adiponectin and obesity related phenotypes including; weight, percent body fat (%BF), percent trunk fat (%TF), percent android fat (%AF), body mass index (BMI), total cholesterol, HDLc, LDLc, glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were analyzed before and after overfeeding. RESULTS: Analysis of variance (ANOVA) and partial correlations were used to compute the effect of overfeeding on adiponectin and its association with adiposity measurements, respectively. Circulating Adiponectin levels significantly increased after the 7-day overfeeding in all three adiposity groups. Moreover, adiponectin at baseline was not significantly different among NW, OW and OB subjects defined by either %BF or BMI. Baseline adiponectin was negatively correlated with weight and BMI for the entire cohort and %TF, glucose, insulin and HOMA-IR in OB. However, after controlling for insulin resistance the correlation of adiponectin with weight, BMI and %TF were nullified. CONCLUSION: Our study provides evidence that the protective response of adiponectin is preserved during a PEC regardless of adiposity. Baseline adiponectin level is not directly associated with obesity status and weight gain in response to short-term overfeeding. However, the significant increase of adiponectin in response to overfeeding indicates the physiological potential for adiponectin to attenuate insulin resistance during the development of obesity. Public Library of Science 2013-08-30 /pmc/articles/PMC3758269/ /pubmed/24023698 http://dx.doi.org/10.1371/journal.pone.0074215 Text en © 2013 Cahill et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cahill, Farrell
Amini, Peyvand
Wadden, Danny
Khalili, Sammy
Randell, Edward
Vasdev, Sudesh
Gulliver, Wayne
Sun, Guang
Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
title Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
title_full Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
title_fullStr Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
title_full_unstemmed Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
title_short Short-Term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status
title_sort short-term overfeeding increases circulating adiponectin independent of obesity status
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758269/
https://www.ncbi.nlm.nih.gov/pubmed/24023698
http://dx.doi.org/10.1371/journal.pone.0074215
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