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Differential Inhibition of Ex-Vivo Tumor Kinase Activity by Vemurafenib in BRAF(V600E) and BRAF Wild-Type Metastatic Malignant Melanoma

BACKGROUND: Treatment of metastatic malignant melanoma patients harboring BRAF(V600E) has improved drastically after the discovery of the BRAF inhibitor, vemurafenib. However, drug resistance is a recurring problem, and prognoses are still very bad for patients harboring BRAF wild-type. Better marke...

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Detalles Bibliográficos
Autores principales:	Tahiri, Andliena, Røe, Kathrine, Ree, Anne H., de Wijn, Rik, Risberg, Karianne, Busch, Christian, Lønning, Per E., Kristensen, Vessela, Geisler, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758344/ https://www.ncbi.nlm.nih.gov/pubmed/24023633 http://dx.doi.org/10.1371/journal.pone.0072692

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