Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients

INTRODUCTION: We studied the impact of small ubiquitin-like modifier 4 (SUMO4) M55V polymorphism on susceptibility to diabetic nephropathy in Iranian type 2 diabetes patients. MATERIALS AND METHODS: The patient group consisted of 50 Iranian type 2 diabetes patients with nephropathy, and the control...

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Autores principales: Shahsavar, Farhad, Jafarzadeh, Mehrzad, Azargoon, Alireza, Hedayati, Mehdi, Asadifar, Behnam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758724/
https://www.ncbi.nlm.nih.gov/pubmed/24019619
http://dx.doi.org/10.4103/0971-6866.116121
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author Shahsavar, Farhad
Jafarzadeh, Mehrzad
Azargoon, Alireza
Hedayati, Mehdi
Asadifar, Behnam
author_facet Shahsavar, Farhad
Jafarzadeh, Mehrzad
Azargoon, Alireza
Hedayati, Mehdi
Asadifar, Behnam
author_sort Shahsavar, Farhad
collection PubMed
description INTRODUCTION: We studied the impact of small ubiquitin-like modifier 4 (SUMO4) M55V polymorphism on susceptibility to diabetic nephropathy in Iranian type 2 diabetes patients. MATERIALS AND METHODS: The patient group consisted of 50 Iranian type 2 diabetes patients with nephropathy, and the control group consisted of 50 Iranian type 2 diabetes patients without nephropathy. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism method for the M55V. RESULTS: The frequency of SUMO4 AA, AG, and GG genotypes were 23%, 18%, and 9% in the patient group and 10%, 22%, and 18% in the control group. There was no significant difference in frequency of SUMO4 genotypes in patients compared to controls. CONCLUSION: These findings indicate that SUMO4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients.
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spelling pubmed-37587242013-09-09 Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients Shahsavar, Farhad Jafarzadeh, Mehrzad Azargoon, Alireza Hedayati, Mehdi Asadifar, Behnam Indian J Hum Genet Original Article INTRODUCTION: We studied the impact of small ubiquitin-like modifier 4 (SUMO4) M55V polymorphism on susceptibility to diabetic nephropathy in Iranian type 2 diabetes patients. MATERIALS AND METHODS: The patient group consisted of 50 Iranian type 2 diabetes patients with nephropathy, and the control group consisted of 50 Iranian type 2 diabetes patients without nephropathy. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism method for the M55V. RESULTS: The frequency of SUMO4 AA, AG, and GG genotypes were 23%, 18%, and 9% in the patient group and 10%, 22%, and 18% in the control group. There was no significant difference in frequency of SUMO4 genotypes in patients compared to controls. CONCLUSION: These findings indicate that SUMO4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3758724/ /pubmed/24019619 http://dx.doi.org/10.4103/0971-6866.116121 Text en Copyright: © Indian Journal of Human Genetics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shahsavar, Farhad
Jafarzadeh, Mehrzad
Azargoon, Alireza
Hedayati, Mehdi
Asadifar, Behnam
Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients
title Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients
title_full Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients
title_fullStr Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients
title_full_unstemmed Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients
title_short Small ubiquitin-like modifier 4 M55V polymorphism is not associated with diabetic nephropathy in Iranian type 2 diabetes patients
title_sort small ubiquitin-like modifier 4 m55v polymorphism is not associated with diabetic nephropathy in iranian type 2 diabetes patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758724/
https://www.ncbi.nlm.nih.gov/pubmed/24019619
http://dx.doi.org/10.4103/0971-6866.116121
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